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 Previous Article

Infect Immun. 1993 November; 61(11): 4937-4939

Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock.

A G Bean, R A Freiberg, S Andrade, S Menon and A Zlotnik

Department of Immunology, DNAX Research Institute, Palo Alto, California 94304.

ABSTRACT

We investigated the ability of interleukin 10 (IL-10) to protect mice against lethal shock induced by staphylococcal enterotoxin B (SEB). Treatment of mice with IL-10 prevented the death of mice injected with SEB in a dose-dependent manner. IL-10-mediated protection was apparent when administered either prior to or concurrent with SEB but was less effective when administered following SEB injection. This observation indicates that IL-10 is capable of regulating T-cell activation in vivo.

Infect Immun. 1993 November; 61(11): 4937-4939




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