This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Flegel, W A Articles by Northoff, H Search for Related Content PubMed PubMed Citation Articles by Flegel, W A Articles by Northoff, H

Prevention of endotoxin-induced monokine release by human low- and high-density lipoproteins and by apolipoprotein A-I.

Abteilung für Transfusionsmedizin, Universität Ulm, Germany.

ABSTRACT

Interaction of endotoxin (lipopolysaccharide [LPS]) with human lipoproteins is known to prevent the LPS-induced activation of human monocytes and release of cytokines (monokines). LPS was exposed to lipoprotein classes separated by ultracentrifugation and to apolipoprotein A-I. Then monocytes were added, and the LPS activation of monocytes was determined by measuring the induced monokines. Failure of LPS to induce monokine release was called LPS inactivation caused by lipoproteins or apolipoproteins. The LPS inactivation is shown to be a function of low-density lipoproteins. High-density lipoproteins inactivate LPS to a much lesser extent. The very-low-density lipoproteins cannot inactivate LPS. Lipid components seemed not absolutely required for LPS inactivation, because purified human apolipoprotein A-I without its physiological lipid complement also inhibits LPS-induced monokine release.

This article has been cited by other articles:

• Votta-Velis, E. G., Minshall, R. D., Visintine, D. J., Castellon, M., Balyasnikova, I. V. (2007). Propofol Attenuates Endotoxin-Induced Endothelial Cell Injury, Angiotensin-Converting Enzyme Shedding, and Lung Edema. Anesth. Analg. 105: 1363-1370 [Abstract] [Full Text]  
• Thaveeratitham, P., Plengpanich, W., Naen-Udorn, W., Patumraj, S., Khovidhunkit, W. (2007). Effects of human apolipoprotein A-I on endotoxin-induced leukocyte adhesion on endothelial cells in vivo and on the growth of Escherichia coli in vitro. Innate Immunity 13: 58-64 [Abstract]  
• Thompson, P. A., Kitchens, R. L. (2006). Native High-Density Lipoprotein Augments Monocyte Responses to Lipopolysaccharide (LPS) by Suppressing the Inhibitory Activity of LPS-Binding Protein. J. Immunol. 177: 4880-4887 [Abstract] [Full Text]  
• Berbee, J. F. P., van der Hoogt, C. C., Kleemann, R., Schippers, E. F., Kitchens, R. L., van Dissel, J. T., Bakker-Woudenberg, I. A. J. M., Havekes, L. M., Rensen, P. C. N. (2006). Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in Gram-negative sepsis. FASEB J. 20: 2162-2164 [Abstract] [Full Text]  
• Christ, M., Klima, T., Grimm, W., Mueller, H.-H., Maisch, B. (2006). Prognostic significance of serum cholesterol levels in patients with idiopathic dilated cardiomyopathy. Eur Heart J 27: 691-699 [Abstract] [Full Text]  
• Tuin, A., Huizinga-Van der Vlag, A., van Loenen-Weemaes, A.-M. M. A., Meijer, D. K. F., Poelstra, K. (2006). On the role and fate of LPS-dephosphorylating activity in the rat liver. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G377-G385 [Abstract] [Full Text]  
• Khovidhunkit, W., Hachem, J. P., Medzihradszky, K. F., Duchateau, P. N., Shigenaga, J. K., Moser, A. H., Movsesyan, I., Naya-Vigne, J., Kane, J. P., Feingold, K. R., Grunfeld, C. (2005). Parotid secretory protein is an HDL-associated protein with anticandidal activity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288: R1306-R1315 [Abstract] [Full Text]  
• Berbee, J. F.P., Havekes, L. M., Rensen, P. C.N. (2005). Apolipoproteins modulate the inflammatory response to lipopolysaccharide. Innate Immunity 11: 97-103 [Abstract]  
• Stoll, L. L., Denning, G. M., Weintraub, N. L. (2004). Potential Role of Endotoxin as a Proinflammatory Mediator of Atherosclerosis. Arterioscler. Thromb. Vasc. Bio. 24: 2227-2236 [Abstract] [Full Text]  
• Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., Grunfeld, C. (2004). Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host. J. Lipid Res. 45: 1169-1196 [Abstract] [Full Text]  
• Recalde, D., Ostos, M. A., Badell, E., Garcia-Otin, A.-L., Pidoux, J., Castro, G., Zakin, M. M., Scott-Algara, D. (2004). Human Apolipoprotein A-IV Reduces Secretion of Proinflammatory Cytokines and Atherosclerotic Effects of a Chronic Infection Mimicked by Lipopolysaccharide. Arterioscler. Thromb. Vasc. Bio. 24: 756-761 [Abstract] [Full Text]  
• Rauchhaus, M., Clark, A. L., Doehner, W., Davos, C., Bolger, A., Sharma, R., Coats, A. J. S., Anker, S. D. (2003). The relationship between cholesterol and survival in patients with chronic heart failure. J Am Coll Cardiol 42: 1933-1940 [Abstract] [Full Text]  
• Ravnskov, U. (2003). High cholesterol may protect against infections and atherosclerosis. QJM 96: 927-934 [Full Text]  
• Bannerman, D. D., Paape, M. J., Hare, W. R., Sohn, E. J. (2003). Increased Levels of LPS-Binding Protein in Bovine Blood and Milk Following Bacterial Lipopolysaccharide Challenge. J DAIRY SCI 86: 3128-3137 [Abstract] [Full Text]  
• Van Amersfoort, E. S., Van Berkel, T. J. C., Kuiper, J. (2003). Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock. Clin. Microbiol. Rev. 16: 379-414 [Abstract] [Full Text]  
• Jackson, A. A., Phillips, G., McClelland, I., Jahoor, F. (2001). Synthesis of hepatic secretory proteins in normal adults consuming a diet marginally adequate in protein. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G1179-G1187 [Abstract] [Full Text]  
• Harris, H. W., Gosnell, J. E., Kumwenda, Z. L. (2000). Review: The lipemia of sepsis: triglyceride-rich lipoproteins as agents of innate immunity. Innate Immunity 6: 421-430 [Abstract]  
• de Haas, C. J. C., Poppelier, M. J. J. G., van Kessel, K. P. M., van Strijp, J. A. G. (2000). Serum Amyloid P Component Prevents High-Density Lipoprotein-Mediated Neutralization of Lipopolysaccharide. Infect. Immun. 68: 4954-4960 [Abstract] [Full Text]  
• Tietge, U. J. F., Maugeais, C., Cain, W., Grass, D., Glick, J. M., de Beer, F. C., Rader, D. J. (2000). Overexpression of Secretory Phospholipase A2 Causes Rapid Catabolism and Altered Tissue Uptake of High Density Lipoprotein Cholesteryl Ester and Apolipoprotein A-I. J. Biol. Chem. 275: 10077-10084 [Abstract] [Full Text]  
• Rose, J. R., Mullarkey, M. A., Christ, W. J., Hawkins, L. D., Lynn, M., Kishi, Y., Wasan, K. M., Peteherych, K., Rossignol, D. P. (2000). Consequences of Interaction of a Lipophilic Endotoxin Antagonist with Plasma Lipoproteins. Antimicrob. Agents Chemother. 44: 504-510 [Abstract] [Full Text]  
• Kitchens, R. L., Wolfbauer, G., Albers, J. J., Munford, R. S. (1999). Plasma Lipoproteins Promote the Release of Bacterial Lipopolysaccharide from the Monocyte Cell Surface. J. Biol. Chem. 274: 34116-34122 [Abstract] [Full Text]  
• de Bont, N., Netea, M. G., Demacker, P. N. M., Verschueren, I., Kullberg, B. J., van Dijk, K. W., van der Meer, J. W. M., Stalenhoef, A. F. H. (1999). Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection. J. Lipid Res. 40: 680-685 [Abstract] [Full Text]  
• Grunfeld, C., Marshall, M., Shigenaga, J. K., Moser, A. H., Tobias, P., Feingold, K. R. (1999). Lipoproteins inhibit macrophage activation by lipoteichoic acid. J. Lipid Res. 40: 245-252 [Abstract] [Full Text]  
• de Haas, C. J. C., van der Tol, M. E., Van Kessel, K. P. M., Verhoef, J., Van Strijp, J. A. G. (1998). A Synthetic Lipopolysaccharide-Binding Peptide Based on Amino Acids 27-39 of Serum Amyloid P Component Inhibits Lipopolysaccharide-Induced Responses in Human Blood. J. Immunol. 161: 3607-3615 [Abstract] [Full Text]  
• Kirikae, T., Hirata, M., Yamasu, H., Kirikae, F., Tamura, H., Kayama, F., Nakatsuka, K., Yokochi, T., Nakano, M. (1998). Protective Effects of a Human 18-Kilodalton Cationic Antimicrobial Protein (CAP18)-Derived Peptide against Murine Endotoxemia. Infect. Immun. 66: 1861-1868 [Abstract] [Full Text]  
• Netea, M. G., de Bont, N., Demacker, P. N. M., Kullberg, B. J., Jacobs, L. E. H., Verver-Jansen, T. J. G., Stalenhoef, A. F. H., Van der Meer, J. W. M. (1998). Lipoprotein(a) Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Production by Human Mononuclear Cells. Infect. Immun. 66: 2365-2367 [Abstract] [Full Text]  
• Hiki, N., Berger, D., Prigl, C., Boelke, E., Wiedeck, H., Seidelmann, M., Staib, L., Kaminishi, M., Oohara, T., Beger, H. G. (1998). Endotoxin Binding and Elimination by Monocytes: Secretion of Soluble CD14 Represents an Inducible Mechanism Counteracting Reduced Expression of Membrane CD14 in Patients with Sepsis and in a Patient with Paroxysmal Nocturnal Hemoglobinuria. Infect. Immun. 66: 1135-1141 [Abstract] [Full Text]  
• Netea, M. G., Demacker, P. N.M., Verver-Jansen, T., Jacobs, L., Jan Kullberg, B., Stalenhoef, A. F.H., Van der Meer, J. W.M. (1997). The dense low-density lipoprotein (LDL) subfractions are more potent than buoyant LDL for binding and neutralization of lipopolysaccharide. Innate Immunity 4: 409-413 [Abstract]  
• Yokota, T., Tani, T., Yoshioka, T., Kodama, M. (1997). Endotoxin concentration by Limulus assay correlates with biological activity in mice and human peripheral blood mononuclear cells. Innate Immunity 4: 307-313 [Abstract]  
• Lemaire, L.C.J.M., van der Poll, T., van Lanschot, J.J.B., Levels, H.M., van der Ende, B., van Deventer, S.J.H., Gouma, D.J. (1997). Human thoracic duct lymph inhibits lipopolysaccharide-induced release of cytokines. Innate Immunity 4: 331-338 [Abstract]  
• Van Oosten, M., Rensen, P. C. N., Van Amersfoort, E. S., Van Eck, M., Van Dam, A.-M., Breve, J. J. P., Vogel, T., Panet, A., Van Berkel, T. J. C., Kuiper, J. (2001). Apolipoprotein E Protects Against Bacterial Lipopolysaccharide-induced Lethality. A NEW THERAPEUTIC APPROACH TO TREAT GRAM-NEGATIVE SEPSIS. J. Biol. Chem. 276: 8820-8824 [Abstract] [Full Text]