This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kemp, M
Right arrow Articles by Theander, T G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kemp, M
Right arrow Articles by Theander, T G

 Previous Article  |  Next Article 

Infect Immun. 1993 March; 61(3): 1069-1073

Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis.

M Kemp, J A Kurtzhals, K Bendtzen, L K Poulsen, M B Hansen, D K Koech, A Kharazmi and T G Theander

Centre for Medical Parasitology, University of Copenhagen, Denmark.

ABSTRACT

Infections in humans by Leishmania donovani parasites can result in a fatal disease, visceral leishmaniasis (VL), or in a self-limiting asymptomatic infection. In murine models of the infection employing Leishmania major, the course of the disease can be directed into a VL-like syndrome by interleukin-4 (IL-4)-producing Th2 cells, or cure may result by Th1 cells secreting gamma interferon (IFN-gamma). The present study examined the potential of human T cells to generate Th1 or Th2 responses to L. donovani. The profiles of IFN-gamma, IL-4, and lymphotoxin secretion after antigen stimulation were analyzed in a panel of L. donovani-reactive CD4+ human T-cell clones generated from individuals who had recovered from VL after antimonial treatment. Two of the T-cell clones produced large amounts of IL-4 without production of IFN-gamma, seven clones produced both IFN-gamma and IL-4, and eight produced only IFN-gamma. This is the first report of a Th1- and Th2-type response in human leishmaniasis. These results suggest that in analogy with murine models, there is a dichotomy in the human T-cell response to L. donovani infections. Preferential activation of IL-4-producing Th2-like cells may be involved in the exacerbation of human VL, whereas activation of IFN-gamma-producing Th1 cells may protect the host from severe disease. Identification of leishmanial antigens activating one or the other type of T cells will be important in the development of vaccines against leishmaniasis.

Infect Immun. 1993 March; 61(3): 1069-1073




This article has been cited by other articles:

  • Sharma, A., Madhubala, R. (2009). Ubiquitin Conjugation of Open Reading Frame F DNA Vaccine Leads to Enhanced Cell-Mediated Immune Response and Induces Protection against Both Antimony-Susceptible and -Resistant Strains of Leishmania donovani. J. Immunol. 183: 7719-7731 [Abstract] [Full Text]  
  • Samant, M., Gupta, R., Kumari, S., Misra, P., Khare, P., Kushawaha, P. K., Sahasrabuddhe, A. A., Dube, A. (2009). Immunization with the DNA-Encoding N-Terminal Domain of Proteophosphoglycan of Leishmania donovani Generates Th1-Type Immunoprotective Response against Experimental Visceral Leishmaniasis. J. Immunol. 183: 470-479 [Abstract] [Full Text]  
  • Dey, A., Sharma, P., Redhu, N. S., Singh, S. (2008). Kinesin Motor Domain of Leishmania donovani as a Future Vaccine Candidate. CVI 15: 836-842 [Abstract] [Full Text]  
  • Basu, R., Bhaumik, S., Haldar, A. K., Naskar, K., De, T., Dana, S. K., Walden, P., Roy, S. (2007). Hybrid Cell Vaccination Resolves Leishmania donovani Infection by Eliciting a Strong CD8+ Cytotoxic T-Lymphocyte Response with Concomitant Suppression of Interleukin-10 (IL-10) but Not IL-4 or IL-13. Infect. Immun. 75: 5956-5966 [Abstract] [Full Text]  
  • Silvestre, R., Cordeiro-Da-Silva, A., Santarem, N., Vergnes, B., Sereno, D., Ouaissi, A. (2007). SIR2-Deficient Leishmania infantum Induces a Defined IFN-{gamma}/IL-10 Pattern That Correlates with Protection. J. Immunol. 179: 3161-3170 [Abstract] [Full Text]  
  • Rosas, L. E., Satoskar, A. A., Roth, K. M., Keiser, T. L., Barbi, J., Hunter, C., de Sauvage, F. J., Satoskar, A. R. (2006). Interleukin-27R (WSX-1/T-Cell Cytokine Receptor) Gene-Deficient Mice Display Enhanced Resistance to Leishmania donovani Infection but Develop Severe Liver Immunopathology. Am. J. Pathol. 168: 158-169 [Abstract] [Full Text]  
  • Basu, R., Bhaumik, S., Basu, J. M., Naskar, K., De, T., Roy, S. (2005). Kinetoplastid Membrane Protein-11 DNA Vaccination Induces Complete Protection against Both Pentavalent Antimonial-Sensitive and -Resistant Strains of Leishmania donovani That Correlates with Inducible Nitric Oxide Synthase Activity and IL-4 Generation: Evidence for Mixed Th1- and Th2-Like Responses in Visceral Leishmaniasis. J. Immunol. 174: 7160-7171 [Abstract] [Full Text]  
  • Ravindran, R., Anam, K., Bairagi, B. C., Saha, B., Pramanik, N., Guha, S. K., Goswami, R. P., Banerjee, D., Ali, N. (2004). Characterization of Immunoglobulin G and Its Subclass Response to Indian Kala-Azar Infection before and after Chemotherapy. Infect. Immun. 72: 863-870 [Abstract] [Full Text]  
  • Lonardoni, M. V. C., Russo, M., Jancar, S. (2000). Essential Role of Platelet-Activating Factor in Control of Leishmania (Leishmania) amazonensis Infection. Infect. Immun. 68: 6355-6361 [Abstract] [Full Text]  
  • Anam, K., Afrin, F., Banerjee, D., Pramanik, N., Guha, S. K., Goswami, R. P., Saha, S. K., Ali, N. (1999). Differential Decline in Leishmania Membrane Antigen-Specific Immunoglobulin G (IgG), IgM, IgE, and IgG Subclass Antibodies in Indian Kala-Azar Patients after Chemotherapy. Infect. Immun. 67: 6663-6669 [Abstract] [Full Text]  
  • Mary, C., Auriault, V., Faugere, B., Dessein, A. J. (1999). Control of Leishmania infantum Infection Is Associated with CD8+ and Gamma Interferon- and Interleukin-5-Producing CD4+ Antigen-Specific T Cells. Infect. Immun. 67: 5559-5566 [Abstract] [Full Text]  
  • Alexander, J, Satoskar, A., Russell, D. (1999). Leishmania species: models of intracellular parasitism. J. Cell Sci. 112: 2993-3002 [Abstract]  
  • Pinelli, E., Rutten, V. P. M. G., Bruysters, M., Moore, P. F., Ruitenberg, E. J. (1999). Compensation for Decreased Expression of B7 Molecules on Leishmania infantum-Infected Canine Macrophages Results in Restoration of Parasite-Specific T-Cell Proliferation and Gamma Interferon Production. Infect. Immun. 67: 237-243 [Abstract] [Full Text]  
  • Cogan, E., Schandene, L., Crusiaux, A., Cochaux, P., Velu, T., Goldman, M. (1994). Clonal Proliferation of Type 2 Helper T Cells in a Man with the Hypereosinophilic Syndrome. NEJM 330: 535-538 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»