This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Raeder, R Articles by Boyle, M D Search for Related Content PubMed PubMed Citation Articles by Raeder, R Articles by Boyle, M D

Association between expression of immunoglobulin G-binding proteins by group A streptococci and virulence in a mouse skin infection model.

Department of Microbiology, Medical College of Ohio, Toledo 43699-0008.

ABSTRACT

In this study, we developed a mouse model of skin infection to test the association between expression of immunoglobulin-binding proteins by and infectivity of group A streptococci. Group A streptococci capable of crossing tissue barriers and establishing a lethal systemic infection in mice showed a higher level of immunoglobulin-binding protein expression. The group A streptococci recovered from the spleen of a mouse that died following a skin infection were found to be more virulent when injected into the skin of naive mice. Together, these results suggest that immunoglobulin-binding protein expression by group A streptococci correlates with their ability to establish invasive skin infections.

This article has been cited by other articles:

• Rezcallah, M. S., Boyle, M. D. P., Sledjeski, D. D. (2004). Mouse skin passage of Streptococcus pyogenes results in increased streptokinase expression and activity. Microbiology 150: 365-371 [Abstract] [Full Text]  
• Smith, T. C., Sledjeski, D. D., Boyle, M. D. P. (2003). Streptococcus pyogenes Infection in Mouse Skin Leads to a Time-Dependent Up-Regulation of Protein H Expression. Infect. Immun. 71: 6079-6082 [Abstract] [Full Text]  
• Janulczyk, R., Ricci, S., Bjorck, L. (2003). MtsABC Is Important for Manganese and Iron Transport, Oxidative Stress Resistance, and Virulence of Streptococcus pyogenes. Infect. Immun. 71: 2656-2664 [Abstract] [Full Text]  
• Song, X.-M., Perez-Casal, J., Bolton, A., Potter, A. A. (2001). Surface-Expressed Mig Protein Protects Streptococcus dysgalactiae against Phagocytosis by Bovine Neutrophils. Infect. Immun. 69: 6030-6037 [Abstract] [Full Text]  
• Limbago, B., McIver, K. S., Penumalli, V., Weinrick, B., Scott, J. R. (2001). Restoration of Mga Function to a Streptococcus pyogenes Strain (M Type 50) That Is Virulent in Mice. Infect. Immun. 69: 1215-1220 [Abstract] [Full Text]  
• Cunningham, M. W. (2000). Pathogenesis of Group A Streptococcal Infections. Clin. Microbiol. Rev. 13: 470-511 [Abstract] [Full Text]  
• Raeder, R., Harokopakis, E., Hollingshead, S., Boyle, M. D. P. (2000). Absence of SpeB Production in Virulent Large Capsular Forms of Group A Streptococcal Strain 64. Infect. Immun. 68: 744-751 [Abstract] [Full Text]  
• Darmstadt, G. L., Mentele, L., Fleckman, P., Rubens, C. E. (1999). Role of Keratinocyte Injury in Adherence of Streptococcus pyogenes. Infect. Immun. 67: 6707-6709 [Abstract] [Full Text]  
• Medina, E., Molinari, G., Rohde, M., Haase, B., Chhatwal, G. S., Guzman, C. A. (1999). Fc-Mediated Nonspecific Binding Between Fibronectin-Binding Protein I of Streptococcus pyogenes and Human Immunoglobulins. J. Immunol. 163: 3396-3402 [Abstract] [Full Text]  
• Kuo, C.-F., Wu, J.-J., Lin, K.-Y., Tsai, P.-J., Lee, S.-C., Jin, Y.-T., Lei, H.-Y., Lin, Y.-S. (1998). Role of Streptococcal Pyrogenic Exotoxin B in the Mouse Model of Group A Streptococcal Infection. Infect. Immun. 66: 3931-3935 [Abstract] [Full Text]  
• Donabedian, H., Boyle, M. D. P. (1998). Clot Formation by Group A Streptococci. Infect. Immun. 66: 2362-2364 [Abstract] [Full Text]  
• Berge, A., Kihlberg, B.-M., Sjoholm, A. G., Bjorck, L. (1997). Streptococcal Protein H Forms Soluble Complement-activating Complexes with IgG, but Inhibits Complement Activation by IgG-coated Targets. J. Biol. Chem. 272: 20774-20781 [Abstract] [Full Text]