This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Christopher-Hennings, J Articles by Hurley, D J Search for Related Content PubMed PubMed Citation Articles by Christopher-Hennings, J Articles by Hurley, D J

Immunocompromise in gnotobiotic pigs induced by verotoxin-producing Escherichia coli (O111:NM).

Department of Veterinary Science, South Dakota State University, Brookings 57007.

ABSTRACT

A verotoxin-producing Escherichia coli serotype O111:NM strain (strain 10049; verotoxin 1 positive) persistently infected experimentally inoculated gnotobiotic pigs, causing attaching-effecting intestinal lesions and chronic diarrhea. Experiments were performed to determine whether persistent infection might be associated with immunocompromise of the host of this organism. Pigs inoculated with this strain had a significant reduction in peripheral blood lymphocytes and lower antibody titers to sheep erythrocytes compared with control pigs. Compared with pigs given a verotoxin-negative pathogenic strain of the same serotype (O111:NM, strain 2430), pigs inoculated with the verotoxin-positive strain had lower peripheral lymphocyte counts and proliferative responses to concanavalin A, phytohemagglutinin, and pokeweed mitogens. The results of this study suggest that strain 10049 has an immunocompromising effect on gnotobiotic pigs.

This article has been cited by other articles:

• Hoffman, M. A., Menge, C., Casey, T. A., Laegreid, W., Bosworth, B. T., Dean-Nystrom, E. A. (2006). Bovine Immune Response to Shiga-Toxigenic Escherichia coli O157:H7. CVI 13: 1322-1327 [Abstract] [Full Text]  
• Winter, K. R. K., Stoffregen, W. C., Dean-Nystrom, E. A. (2004). Shiga Toxin Binding to Isolated Porcine Tissues and Peripheral Blood Leukocytes. Infect. Immun. 72: 6680-6684 [Abstract] [Full Text]  
• Menge, C., Stamm, I., Blessenohl, M., Wieler, L. H., Baljer, G. (2003). Verotoxin 1 from Escherichia coli Affects Gb3/CD77+ Bovine Lymphocytes Independent of Interleukin-2, Tumor Necrosis Factor-{alpha}, and Interferon-{alpha}. Exp. Biol. Med. 228: 377-386 [Abstract] [Full Text]  
• Herbelin, C. J., Chirillo, S. C., Melnick, K. A., Whittam, T. S. (2000). Gene Conservation and Loss in the mutS-rpoS Genomic Region of Pathogenic Escherichia coli. J. Bacteriol. 182: 5381-5390 [Abstract] [Full Text]  
• Matise, I., Sirinarumitr, T., Bosworth, B. T., Moon, H. W. (2000). Vascular Ultrastructure and DNA Fragmentation in Swine Infected with Shiga Toxin-Producing Escherichia coli. Vet Pathol 37: 318-327 [Abstract] [Full Text]  
• Menge, C., Wieler, L. H., Schlapp, T., Baljer, G. (1999). Shiga Toxin 1 from Escherichia coli Blocks Activation and Proliferation of Bovine Lymphocyte Subpopulations In Vitro. Infect. Immun. 67: 2209-2217 [Abstract] [Full Text]