This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nakane, A Articles by Minagawa, T Search for Related Content PubMed PubMed Citation Articles by Nakane, A Articles by Minagawa, T

An anti-CD3 monoclonal antibody protects mice against a lethal infection with Listeria monocytogenes through induction of endogenous cytokines.

Department of Microbiology, Hokkaido University School of Medicine, Sapporo, Japan.

ABSTRACT

Mice were protected against a lethal infection with Listeria monocytogenes when treated with low doses of an anti-CD3 monoclonal antibody (MAb). Injection of anti-CD3 MAb induced rapid production of endogenous tumor necrosis factor (TNF) in the spleens and endogenous gamma interferon (IFN-gamma) in the bloodstreams and spleens of mice. Administration of anti-Thy1.2 MAb or a combination of anti-CD4 MAb and anti-CD8 MAb resulted in suppression of anti-CD3 MAb-induced endogenous cytokine production and antilisterial resistance. Alternatively, in vivo depletion of anti-CD3 MAb-induced TNF and IFN-gamma by the simultaneous administration of antibodies against TNF and IFN-gamma suppressed anti-CD3 MAb-induced antilisterial resistance. Moreover, injection of anti-complement receptor type 3 (Mac-1, CD11b) resulted in inhibition of anti-CD3 MAb-induced antilisterial resistance. These results suggest that the preventive effect of anti-CD3 MAb might be due to activation of phagocytes by TNF and IFN-gamma induced by stimulating CD4+ T cells and CD8+ T cells with the MAb. Furthermore, treatment with anti-CD3 MAb did not inhibit establishment of acquired resistance against secondary infection with L. monocytogenes.

This article has been cited by other articles:

• Schwedler, S. B., Amann, K., Wernicke, K., Krebs, A., Nauck, M., Wanner, C., Potempa, L. A., Galle, J. (2005). Native C-Reactive Protein Increases Whereas Modified C-Reactive Protein Reduces Atherosclerosis in Apolipoprotein E-Knockout Mice. Circulation 112: 1016-1023 [Abstract] [Full Text]  
• Miura, T., Kudo, T., Matsuki, A., Sekikawa, K., Tagawa, Y.-I., Iwakura, Y., Nakane, A. (2001). Effect of 6-Hydroxydopamine on Host Resistance against Listeria monocytogenes Infection. Infect. Immun. 69: 7234-7241 [Abstract] [Full Text]