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Infect Immun. 1993 July; 61(7): 2822-2826

Mapping of immunoreactive sites of pneumococcal pneumolysin by use of synthetic peptides.

P Salo, A Närvänen and M Leinonen

National Public Health Institute, Helsinki, Finland.

ABSTRACT

In the search for better diagnostic tools and improved vaccines against pneumococcal diseases, continuous antigenic sites of the pneumococcal pneumolysin molecule were identified with partially overlapping synthetic peptides. Peptides were derived from the predicted amino acid sequence according to the known DNA sequence of pneumolysin. The immunoreactivities of the peptides were studied by enzyme immunoassay with seven human serum samples and three rabbit hyperimmune serum samples. Two immunoreactive sites in the overlapping peptides at the amino-terminal end of the pneumolysin molecule were identified in this study. Two common immunoreactive sites for both human and rabbit sera were demonstrated.

Infect Immun. 1993 July; 61(7): 2822-2826




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Copyright © 1993 by the American Society for Microbiology. All rights reserved.