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Infect Immun. 1993 August; 61(8): 3530-3532

Enhancement of susceptibility of CB-17 mice to systemic candidiasis by poly(I . C)-induced interferon.

J Jensen and E Balish

Department of Surgery, University of Wisconsin Medical School, Madison 53706.

ABSTRACT

Poly(I . C) enhanced the susceptibility of CB-17 (BALB/c) mice to acute systemic candidiasis. Poly(I . C), supernatants from poly(I . C)-treated macrophages, or alpha and beta interferons suppressed macrophage candidacidal activity in vitro. Thus, poly(I . C)-induced interferons may enhance the susceptibility of CB-17 mice to candidiasis by suppressing macrophage candidacidal activity in an autocrine fashion.


Infect Immun. 1993 August; 61(8): 3530-3532







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