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Infection and Immunity, November 1994, p. 5198-5200, Vol. 62, No. 11
0019-9567/1994/$04.00+0     DOI:

research-article

Enhancement of anti-Shigella lipopolysaccharide (LPS) response by addition of the cholera toxin B subunit to oral and intranasal proteosome-Shigella flexneri 2a LPS vaccines.

Medical Corps, Israel Defence Force, Military Post 02149, Rehovot, Israel.

ABSTRACT

Addition of the cholera toxin B subunit to oral and intranasal proteosome-Shigella flexneri 2a lipopolysaccharide vaccines improved their immunogenicities. Enhancement of anti-O-Shigella immunoglobulin A levels was most evident in lung lavages following oral immunization and in lung and intestinal fluids when suboptimal doses were used with either immunization route.

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