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Infection and Immunity, December 1994, p. 5659-5663, Vol. 62, No. 12
0019-9567/1994/$04.00+0     DOI:

research-article

Evidence for naturally occurring recombination in the gene encoding the major outer membrane protein of lymphogranuloma venereum isolates of Chlamydia trachomatis.

Southampton University Medical School, Southampton General Hospital, United Kingdom.

ABSTRACT

The nucleotide sequence of the major outer membrane protein gene (omp1) was determined for three geographically distinct lymphogranuloma venereum isolates which were serologically untypeable. The three omp1 sequences were hybrids of serovars L1 and L2, containing a putative DNA recombination site in variable segment 2. Efforts to manipulate the chlamydial genome in vitro by recombination should be intensified.

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