This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Koide, Y Articles by Yoshida, A Search for Related Content PubMed PubMed Citation Articles by Koide, Y Articles by Yoshida, A

 Previous Article  |  Next Article 

Infection and Immunity, March 1994, p. 948-955, Vol. 62, No. 3
0019-9567/1994/$04.00+0     DOI:

research-article

The signal transduction mechanism responsible for gamma interferon-induced indoleamine 2,3-dioxygenase gene expression.

Department of Microbiology, Hamamatsu University School of Medicine, Japan.

ABSTRACT

We examined the signal transduction mechanism responsible for the gamma interferon-induced indoleamine 2,3-dioxygenase (IDO) gene expression in a human monocytic cell line, THP-1. Our results suggest that gamma interferon-induced activation of protein tyrosine kinase is a prerequisite for gene expression and that activation of protein kinase C and another unknown signal(s), both of which are transduced by the protein tyrosine kinase, synergistically induce IDO gene expression. Neither Ca2+ influx nor cyclic nucleotide-dependent kinases were suggested to be involved in the signaling pathway.

This article has been cited by other articles:

• Jasperson, L. K., Bucher, C., Panoskaltsis-Mortari, A., Taylor, P. A., Mellor, A. L., Munn, D. H., Blazar, B. R. (2008). Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality. Blood 111: 3257-3265 [Abstract] [Full Text]  
• El-Etr, S. H., Yan, L., Cirillo, J. D. (2001). Fish Monocytes as a Model for Mycobacterial Host-Pathogen Interactions. Infect. Immun. 69: 7310-7317 [Abstract] [Full Text]  
• Pantoja, L. G., Miller, R. D., Ramirez, J. A., Molestina, R. E., Summersgill, J. T. (2001). Characterization of Chlamydia pneumoniae Persistence in HEp-2 Cells Treated with Gamma Interferon. Infect. Immun. 69: 7927-7932 [Abstract] [Full Text]  
• Munn, D. H., Shafizadeh, E., Attwood, J. T., Bondarev, I., Pashine, A., Mellor, A. L. (1999). Inhibition of  T Cell Proliferation by Macrophage Tryptophan Catabolism. J. Exp. Med. 189: 1363-1372 [Abstract] [Full Text]