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Infection and Immunity, June 1994, p. 2614-2618, Vol. 62, No. 6
0019-9567/1994/$04.00+0     DOI:

research-article

Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis.

Department of Protozoology, Oswaldo Cruz Institute-FIOCRUZ, Rio de Janeiro, Brazil.

ABSTRACT

Fourteen patients suffering from American cutaneous leishmaniasis were studied. Assays of the lymphocyte proliferative response induced in vitro by Leishmania braziliensis antigens were performed. After 5 days in culture, L. braziliensis-stimulated blast T cells were harvested for CD4+ and CD8+ phenotype analysis. When results before and at the end of therapy were compared, leishmaniasis patients showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ blast T cells in cultures. The levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured. These results show a pattern of higher proportions of Leishmania-reactive CD8+ T cells and lower proportions of Leishmania-reactive CD4+ T cells after cure.

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