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Infection and Immunity, July 1994, p. 3004-3007, Vol. 62, No. 7
0019-9567/1994/$04.00+0     DOI:

research-article

Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.

ABSTRACT

Melanized Cryptococcus neoformans cells were less susceptible than nonmelanized cells to the fungicidal effects of nitrogen- and oxygen-derived oxidants. The results support the hypothesis that the phenoloxidase enzyme system contributes to virulence by protecting C. neoformans against nitrogen- and oxygen-derived oxidative antimicrobial molecules produced by immune effector cells.

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