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Infect. Immun., Nov 1995, 4535-4539, Vol 63, No. 11
Copyright © 1995, American Society for Microbiology

Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi

B Stevenson, TG Schwan and PA Rosa
Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.

Previous studies have demonstrated that Borrelia burgdorferi in the midguts of infected ticks shows increased expression of the antigenic outer surface protein OspC after the ticks have ingested a blood meal. This differential expression is at least partly due to a change in temperature, as an increase in OspC levels is also observed when cultures are shifted from 23 to 35 degrees C. Immunoblotting of bacterial lysates with sera from infected mice indicated that the levels of several additional antigens were also increased in bacterial cultures shifted to 35 degrees C; we have identified one antigen as OspE. We have also observed differential expression of OspF, which has been proposed to be coexpressed in an operon with the gene encoding OspE.


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  • Heikkila, T., Seppala, I., Saxen, H., Panelius, J., Peltomaa, M., Julin, T., Carlsson, S.-A., Lahdenne, P. (2002). Recombinant BBK32 Protein in Serodiagnosis of Early and Late Lyme Borreliosis. J. Clin. Microbiol. 40: 1174-1180 [Abstract] [Full Text]  
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  • Anguita, J., Samanta, S., Revilla, B., Suk, K., Das, S., Barthold, S. W., Fikrig, E. (2000). Borrelia burgdorferi Gene Expression In Vivo and Spirochete Pathogenicity. Infect. Immun. 68: 1222-1230 [Abstract] [Full Text]  
  • Caimano, M. J., Yang, X., Popova, T. G., Clawson, M. L., Akins, D. R., Norgard, M. V., Radolf, J. D. (2000). Molecular and Evolutionary Characterization of the cp32/18 Family of Supercoiled Plasmids in Borrelia burgdorferi 297. Infect. Immun. 68: 1574-1586 [Abstract] [Full Text]  
  • Zuckert, W. R., Barbour, A. G. (2000). Stability of Borrelia burgdorferi bdr Loci In Vitro and In Vivo. Infect. Immun. 68: 1727-1730 [Abstract] [Full Text]  
  • Indest, K. J., Philipp, M. T. (2000). DNA-Binding Proteins Possibly Involved in Regulation of the Post-Logarithmic-Phase Expression of Lipoprotein P35 in Borrelia burgdorferi. J. Bacteriol. 182: 522-525 [Abstract] [Full Text]  
  • Wieneke, C. A., Lovrich, S. D., Callister, S. M., Jobe, D. A., Marks, J. A., Schell, R. F. (2000). Evaluation of Whole-Cell and OspC Enzyme-Linked Immunosorbent Assays for Discrimination of Early Lyme Borreliosis from OspA Vaccination. J. Clin. Microbiol. 38: 313-317 [Abstract] [Full Text]  
  • Schwan, T. G., Piesman, J. (2000). Temporal Changes in Outer Surface Proteins A and C of the Lyme Disease-Associated Spirochete, Borrelia burgdorferi, during the Chain of Infection in Ticks and Mice. J. Clin. Microbiol. 38: 382-388 [Abstract] [Full Text]  
  • Jobe, D. A., Rawal, N., Schell, R. F., Callister, S. M. (1999). Detection of Borreliacidal Antibodies in Lyme Borreliosis Patient Sera Containing Antimicrobial Agents. CVI 6: 930-933 [Abstract] [Full Text]  
  • Yang, X., Popova, T. G., Hagman, K. E., Wikel, S. K., Schoeler, G. B., Caimano, M. J., Radolf, J. D., Norgard, M. V. (1999). Identification, Characterization, and Expression of Three New Members of the Borrelia burgdorferi Mlp (2.9) Lipoprotein Gene Family. Infect. Immun. 67: 6008-6018 [Abstract] [Full Text]  
  • Carroll, J. A., Garon, C. F., Schwan, T. G. (1999). Effects of Environmental pH on Membrane Proteins in Borrelia burgdorferi. Infect. Immun. 67: 3181-3187 [Abstract] [Full Text]  
  • Zuckert, W. R., Meyer, J., Barbour, A. G. (1999). Comparative Analysis and Immunological Characterization of the Borrelia Bdr Protein Family. Infect. Immun. 67: 3257-3266 [Abstract] [Full Text]  
  • Obonyo, M., Munderloh, U. G., Fingerle, V., Wilske, B., Kurtti, T. J. (1999). Borrelia burgdorferi in Tick Cell Culture Modulates Expression of Outer Surface Proteins A and C in Response to Temperature. J. Clin. Microbiol. 37: 2137-2141 [Abstract] [Full Text]  
  • El Hage, N., Lieto, L. D., Stevenson, B. (1999). Stability of erp Loci during Borrelia burgdorferi Infection: Recombination Is Not Required for Chronic Infection of Immunocompetent Mice. Infect. Immun. 67: 3146-3150 [Abstract] [Full Text]  
  • Akins, D. R., Caimano, M. J., Yang, X., Cerna, F., Norgard, M. V., Radolf, J. D. (1999). Molecular and Evolutionary Analysis of Borrelia burgdorferi 297 Circular Plasmid-Encoded Lipoproteins with OspE- and OspF-Like Leader Peptides. Infect. Immun. 67: 1526-1532 [Abstract] [Full Text]  
  • de Silva, A. M., Zeidner, N. S., Zhang, Y., Dolan, M. C., Piesman, J., Fikrig, E. (1999). Influence of Outer Surface Protein A Antibody on Borrelia burgdorferi within Feeding Ticks. Infect. Immun. 67: 30-35 [Abstract] [Full Text]  
  • Wang, I.-N., Dykhuizen, D. E., Qiu, W., Dunn, J. J., Bosler, E. M., Luft, B. J. (1999). Genetic Diversity of ospC in a Local Population of Borrelia burgdorferi sensu stricto. Genetics 151: 15-30 [Abstract] [Full Text]  
  • Ramamoorthy, R., Philipp, M. T. (1998). Differential Expression of Borrelia burgdorferi Proteins during Growth In Vitro. Infect. Immun. 66: 5119-5124 [Abstract] [Full Text]  
  • Cassatt, D. R., Patel, N. K., Ulbrandt, N. D., Hanson, M. S. (1998). DbpA, but Not OspA, Is Expressed by Borrelia burgdorferi during Spirochetemia and Is a Target for Protective Antibodies. Infect. Immun. 66: 5379-5387 [Abstract] [Full Text]  
  • Mathiesen, M. J., Holm, A., Christiansen, M., Blom, J., Hansen, K., Ostergaard, S., Theisen, M. (1998). The Dominant Epitope of Borrelia garinii Outer Surface Protein C Recognized by Sera from Patients with Neuroborreliosis Has a Surface-Exposed Conserved Structural Motif. Infect. Immun. 66: 4073-4079 [Abstract] [Full Text]  


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