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Infect. Immun., Aug 1995, 3231-3234, Vol 63, No. 8
Copyright © 1995, American Society for Microbiology

T-cell cytokine responses in human infection with Mycobacterium tuberculosis

M Zhang, Y Lin, DV Iyer, J Gong, JS Abrams and PF Barnes
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.

Compared with healthy tuberculin reactors, Mycobacterium tuberculosis- stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4+ cells. At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 responses.


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