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Infect. Immun., 03 1996, 714-718, Vol 64, No. 3
Copyright © 1996, American Society for Microbiology

Interleukins 6 and 11 protect mice from mortality in a staphylococcal enterotoxin-induced toxic shock model

BE Barton, J Shortall and JV Jackson
Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.

BALB/By mice given doses of D-galactosamine plus Staphylococcus aureus enterotoxin B die within 48 h of administration. The cause of death is a syndrome much like toxic shock syndrome in humans. We used this model to investigate the role of two cytokines, interleukin 6 and interleukin 11, which share the signal transducing subunit, gp130, of their respective receptors. We observed that pretreatment of mice with antibody to interleukin 6 increased mortality from 55% to nearly 90% (P < 0.001), while pretreatment with either cytokine reduced death. The protection was dose dependent; however, interleukin 6 was about 10-fold more potent that interleukin 11. These data indicate that endogenous interleukin 6 plays a protective role in attenuating acute inflammatory responses; furthermore, interleukin 6 and interleukin 11 can abrogate T- cell activation due to triggering by superantigen. A possible clinical role for these cytokines in the treatment of toxic shock merits further investigation.


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