This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Capo, C. Articles by Mege, J. L. Search for Related Content PubMed PubMed Citation Articles by Capo, C. Articles by Mege, J. L.

 Previous Article  |  Next Article 

Infect. Immun., May 1996, 1638-1642, Vol 64, No. 5
Copyright © 1996, American Society for Microbiology

Upregulation of tumor necrosis factor alpha and interleukin-1 beta in Q fever endocarditis

C Capo, F Zugun, A Stein, G Tardei, H Lepidi, D Raoult and JL Mege
Unite des Rickettsies, Centre National de la Recherche Scientifique EPJ 0054, Marseille, France.

The occurrence of Q fever endocarditis likely involves some alterations in the responses of monocytes, the in vivo targets of Coxiella burnetii. To test this hypothesis, the production of the inflammatory cytokines tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 was assessed in monocytes from patients with Q fever endocarditis. Spontaneous transcription and secretion of tumor necrosis factor and interleukin-1 were significantly higher in patient monocytes than in healthy controls. The interleukin-6 transcripts were also upregulated in patient cells. Moreover, in patients with recent endocarditis exhibiting high titers of immunoglobulin G directed to C. burnetii in phase I, monocytes released significantly higher levels of tumor necrosis factor and interleukin-1 than in patients with stabilized endocarditis. Immunoglobulin G titers and the overproduction of tumor necrosis factor and interleukin-1 were significantly correlated. Hence, the overproduction of inflammatory cytokines might be a marker of disease activity.

This article has been cited by other articles:

• Honstettre, A., Meghari, S., Nunes, J. A., Lepidi, H., Raoult, D., Olive, D., Mege, J.-L. (2006). Role for the CD28 Molecule in the Control of Coxiella burnetii Infection. Infect. Immun. 74: 1800-1808 [Abstract] [Full Text]  
• Gouriet, F., Bothelo-Nevers, E., Coulibaly, B., Raoult, D., Casalta, J.-P. (2006). Evaluation of Sedimentation Rate, Rheumatoid Factor, C-Reactive Protein, and Tumor Necrosis Factor for the Diagnosis of Infective Endocarditis. CVI 13: 301-301 [Full Text]  
• Andoh, M., Naganawa, T., Hotta, A., Yamaguchi, T., Fukushi, H., Masegi, T., Hirai, K. (2003). SCID Mouse Model for Lethal Q Fever. Infect. Immun. 71: 4717-4723 [Abstract] [Full Text]  
• Ghigo, E., Capo, C., Raoult, D., Mege, J.-L. (2001). Interleukin-10 Stimulates Coxiella burnetii Replication in Human Monocytes through Tumor Necrosis Factor Down-Modulation: Role in Microbicidal Defect of Q Fever. Infect. Immun. 69: 2345-2352 [Abstract] [Full Text]  
• Dellacasagrande, J., Ghigo, E., Machergui-El, S., Hammami, , Toman, R., Raoult, D., Capo, C., Mege, J.-L. (2000). alpha vbeta 3 Integrin and Bacterial Lipopolysaccharide Are Involved in Coxiella burnetii-Stimulated Production of Tumor Necrosis Factor by Human Monocytes. Infect. Immun. 68: 5673-5678 [Abstract] [Full Text]  
• Dellacasagrande, J., Moulin, P. A., Guilianelli, C., Capo, C., Raoult, D., Grau, G. E., Mege, J.-L. (2000). Reduced Transendothelial Migration of Monocytes Infected by Coxiella burnetii. Infect. Immun. 68: 3784-3786 [Abstract] [Full Text]  
• Dellacasagrande, J., Ghigo, E., Capo, C., Raoult, D., Mege, J.-L. (2000). Coxiella burnetii Survives in Monocytes from Patients with Q Fever Endocarditis: Involvement of Tumor Necrosis Factor. Infect. Immun. 68: 160-164 [Abstract] [Full Text]  
• Maurin, M., Raoult, D. (1999). Q Fever. Clin. Microbiol. Rev. 12: 518-553 [Abstract] [Full Text]  
• Dellacasagrande, J., Capo, C., Raoult, D., Mege, J.-L. (1999). IFN-{gamma}-Mediated Control of Coxiella burnetii Survival in Monocytes: The Role of Cell Apoptosis and TNF. J. Immunol. 162: 2259-2265 [Abstract] [Full Text]  
• Meconi, S., Jacomo, V., Boquet, P., Raoult, D., Mege, J.-L., Capo, C. (1998). Coxiella burnetii Induces Reorganization of the Actin Cytoskeleton in Human Monocytes. Infect. Immun. 66: 5527-5533 [Abstract] [Full Text]  
• BROWN, M., GRIFFIN, G. E (1998). Immune responses in endocarditis. Heart 79: 1-2 [Full Text]