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Infect. Immun., May 1996, 1666-1671, Vol 64, No. 5
Copyright © 1996, American Society for Microbiology

Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria

DE Lanar, JA Tine, C de Taisne, MC Seguin, WI Cox, JP Winslow, LA Ware, EB Kauffman, D Gordon, WR Ballou, E Paoletti and JC Sadoff
Department of Immunology, Walter Reed Army Institute of Research, Washington, DC 20307, USA.

NYVAC-based vaccinia virus recombinants expressing the circumsporozoite protein (CSP) were evaluated in the Plasmodium berghei rodent malaria model system. Immunization of mice with a NYVAC-based CSP recombinant elicited a high level of protection (60 to 100%). Protection did not correlate with CS repeat-specific antibody responses and was abrogated by in vivo CD8+ T-cell depletion. Protection was not enhanced by modification of the subcellular localization of CSP. These results suggest the potential of poxvirus-based vectors for the development of vaccine candidates for human malaria.

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