This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Eichenbaum, Z. Articles by Scott, J. R. Search for Related Content PubMed PubMed Citation Articles by Eichenbaum, Z. Articles by Scott, J. R.

 Previous Article  |  Next Article 

Infect. Immun., 06 1996, 1956-1960, Vol 64, No. 6
Copyright © 1996, American Society for Microbiology

Iron starvation causes release from the group A streptococcus of the ADP-ribosylating protein called plasmin receptor or surface glyceraldehyde-3-phosphate-dehydrogenase

Z Eichenbaum, BD Green and JR Scott
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322, USA.

In many pathogenic bacteria, iron starvation serves as an environmental signal that triggers the expression of virulence factors, many of which are found on the cell surface or secreted into the culture supernatant. Using the chelating agent nitrilotriacetic acid, we have established conditions for iron starvation of the important human pathogen Streptococcus pyogenes (the group A streptococcus) and determined that iron limitation results in the specific appearance of several new proteins in the culture supernatant. One of these supernatant proteins is the ADP-ribosylating protein known as streptococcal plasmin receptor (Plr) or as the streptococcal surface glyceraldehyde-3-phosphate- dehydrogenase because of its other activities. Upon iron starvation, Plr is specifically released into the culture supernatant in a time- dependent manner, and its appearance in the supernatant is not accompanied by induction of plr mRNA synthesis. Release of Plr from the bacteria may be important for the virulence of group A streptococci and the manifestation of diseases.

This article has been cited by other articles:

• Hurmalainen, V., Edelman, S., Antikainen, J., Baumann, M., Lahteenmaki, K., Korhonen, T. K. (2007). Extracellular proteins of Lactobacillus crispatus enhance activation of human plasminogen. Microbiology 153: 1112-1122 [Abstract] [Full Text]  
• Bates, C. S., Toukoki, C., Neely, M. N., Eichenbaum, Z. (2005). Characterization of MtsR, a New Metal Regulator in Group A Streptococcus, Involved in Iron Acquisition and Virulence. Infect. Immun. 73: 5743-5753 [Abstract] [Full Text]  
• Bates, C. S., Montanez, G. E., Woods, C. R., Vincent, R. M., Eichenbaum, Z. (2003). Identification and Characterization of a Streptococcus pyogenes Operon Involved in Binding of Hemoproteins and Acquisition of Iron. Infect. Immun. 71: 1042-1055 [Abstract] [Full Text]  
• Terao, Y., Kawabata, S., Nakata, M., Nakagawa, I., Hamada, S. (2002). Molecular Characterization of a Novel Fibronectin-binding Protein of Streptococcus pyogenes Strains Isolated from Toxic Shock-like Syndrome Patients. J. Biol. Chem. 277: 47428-47435 [Abstract] [Full Text]  
• Lei, B., Smoot, L. M., Menning, H. M., Voyich, J. M., Kala, S. V., Deleo, F. R., Reid, S. D., Musser, J. M. (2002). Identification and Characterization of a Novel Heme-Associated Cell Surface Protein Made by Streptococcus pyogenes. Infect. Immun. 70: 4494-4500 [Abstract] [Full Text]  
• Smoot, L. M., Smoot, J. C., Graham, M. R., Somerville, G. A., Sturdevant, D. E., Migliaccio, C. A. L., Sylva, G. L., Musser, J. M. (2001). Global differential gene expression in response to growth temperature alteration in group A Streptococcus. Proc. Natl. Acad. Sci. USA 10.1073/pnas.191267598v1 [Abstract] [Full Text]  
• Cunningham, M. W. (2000). Pathogenesis of Group A Streptococcal Infections. Clin. Microbiol. Rev. 13: 470-511 [Abstract] [Full Text]  
• Modun, B., Williams, P. (1999). The Staphylococcal Transferrin-Binding Protein Is a Cell Wall Glyceraldehyde-3-Phosphate Dehydrogenase. Infect. Immun. 67: 1086-1092 [Abstract] [Full Text]  
• Beinke, C., Laarmann, S., Wachter, C., Karch, H., Greune, L., Schmidt, M. A. (1998). Diffusely Adhering Escherichia coli Strains Induce Attaching and Effacing Phenotypes and Secrete Homologs of Esp Proteins. Infect. Immun. 66: 528-539 [Abstract] [Full Text]  
• Kolenbrander, P. E., Andersen, R. N., Baker, R. A., Jenkinson, H. F. (1998). The Adhesion-Associated sca Operon in Streptococcus gordonii Encodes an Inducible High-Affinity ABC Transporter for Mn2+ Uptake. J. Bacteriol. 180: 290-295 [Abstract] [Full Text]  
• Smoot, L. M., Smoot, J. C., Graham, M. R., Somerville, G. A., Sturdevant, D. E., Migliaccio, C. A. L., Sylva, G. L., Musser, J. M. (2001). Global differential gene expression in response to growth temperature alteration in group A Streptococcus. Proc. Natl. Acad. Sci. USA 98: 10416-10421 [Abstract] [Full Text]