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Infect. Immun., 10 1997, 4334-4336, Vol 65, No. 10
Copyright © 1997, American Society for Microbiology

Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice

J Anguita, S Samanta, SW Barthold and E Fikrig
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA.

The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T-cell responses leads to an exacerbation of joint inflammation.

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