Infect. Immun., Mar 1997, 1098-1100, Vol 65, No. 3
Copyright © 1997, American Society for Microbiology

Humoral immune responses of Solomon Islanders to the merozoite surface antigen 2 of Plasmodium falciparum show pronounced skewing towards antibodies of the immunoglobulin G3 subclass

CM Rzepczyk, K Hale, N Woodroffe, A Bobogare, P Csurhes, A Ishii and A Ferrante
Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Herston, Brisbane. christir@qimr.edu.au

The immunoglobulin G (IgG) subclass distribution of antibodies to merozoite surface antigen 2 of Plasmodium falciparum in Solomon Islanders showed marked skewing towards the IgG3 subclass. This was not observed with crude P. falciparum schizont antigen. IgG3 responses may be short-lived and require repeated restimulation for their maintenance. This may be provided by persistent infection (premunition) or new infections.

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