This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Klein, B. S. Articles by Hogan, L. H. Search for Related Content PubMed PubMed Citation Articles by Klein, B. S. Articles by Hogan, L. H.

 Previous Article  |  Next Article 

Infect. Immun., Apr 1997, 1505-1509, Vol 65, No. 4
Copyright © 1997, American Society for Microbiology

African strains of Blastomyces dermatitidis that do not express surface adhesin WI-1

BS Klein, BD Aizenstein and LH Hogan
Department of Pediatrics, University of Wisconsin Medical School, Madison 53792, USA.

African strains of Blastomyces dermatitidis differ from North American strains in their growth, morphology, and clinical disease phenotype. In addition, two serotypes, designated 1 and 2, have been described. We investigated African strains of B. dermatitidis for expression of the surface protein adhesin WI-1 and found that serotype 2 strains do not express it because they lack the coding sequence in their genome. The defect will make the strains useful for gene complementation and for testing the pathogenetic role of the WI-1 adhesin.