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Infect. Immun., Jun 1997, 2451-2453, Vol 65, No. 6
Copyright © 1997, American Society for Microbiology

Avirulence of LT2 strains of Salmonella typhimurium results from a defective rpoS gene

WE Swords, BM Cannon and WH Benjamin Jr
Department of Microbiology, University of Alabama at Birmingham, USA.

In order to identify the genetic basis for the attenuation of Salmonella typhimurium LT2 strains, experiments were performed to identify a gene(s) which restores virulence to an avirulent LT2 strain. These and further experiments confirmed that an rpoS mutation is the sole determinant of the attenuation of S. typhimurium LT2.

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