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Infect. Immun., 08 1997, 3267-3270, Vol 65, No. 8
Copyright © 1997, American Society for Microbiology

The baboon as a nonhuman primate model for assessing the effects of maternal immunization with Haemophilus influenzae type b polysaccharide vaccines

MH Shearer, AH Lucas, PW Anderson, KD Carey, HB Jenson, TC Chanh, JR Stanley and RC Kennedy
Department of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City 73190, USA.

These studies were performed to assess the utility of the baboon as a nonhuman primate model to evaluate vaccines for use in humans. Specifically, we examined the antibody response of baboons immunized during the third trimester of pregnancy with Haemophilus influenzae type b (Hib) polyribosylribitol phosphate (PRP) conjugate and unconjugated polysaccharide vaccines. Some of the vaccinated mothers failed to respond to a single immunization with unconjugated Hib PRP. Specific Hib PRP immunoglobulin G (IgG) but not IgM antibodies cross the baboon placenta and are detected in the offspring. Higher-titer baboon anti-Hib PRP did not express two previously defined cross- reactive human anti-Hib PRP idiotypes and was biased towards lambda light-chain expression. Spectrotype analysis indicated that baboon anti- Hib PRP was restricted in heterogeneity and oligoclonal.


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Copyright © 1997 by the American Society for Microbiology. All rights reserved.