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Infect. Immun., 09 1997, 3966-3969, Vol 65, No. 9
Copyright © 1997, American Society for Microbiology

A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis

Y Abiko, N Ogura, U Matsuda, K Yanagi and H Takiguchi
Department of Biochemistry, Nihon University School of Dentistry at Matsudo, Chiba, Japan. yabiko@mascat.nihon-u.ac.jp

A B-cell line producing a human monoclonal antibody (HuMAb) against a recombinant 40-kDa outer membrane protein (OMP) of Porphyromonas gingivalis was constructed by in vivo immunization of a severe combined immunodeficiency C.B.-17/Icr mouse, which had been injected with human peripheral blood lymphocytes, with recombinant 40-kDa OMP and subsequent Epstein-Barr virus immortalization of B cells isolated from the spleen of the mouse. This HuMAb inhibited coaggregation between P. gingivalis vesicles and Actinomyces naeslundii cells.

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