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Infect. Immun., Jan 1998, 373-375, Vol 66, No. 1
Copyright © 1998, American Society for Microbiology

Immunization of Aotus monkeys with recombinant Plasmodium falciparum hybrid proteins does not reproducibly result in protection from malaria infection

CH Kocken, E Hundt, B Knapp, D Brazel, B Enders, DL Narum, JA Wubben and AW Thomas
Biomedical Primate Research Centre, Department of Parasitology, Rijswijk, The Netherlands. kocken@bprc.nl

Plasmodium falciparum antigens SERP, HRPII, MSAI, and 41-3 have shown promise as vaccine components. This study aimed at reproducing and extending previous results using three hybrid molecules. Antibody responses were reproduced in Aotus monkeys, but solid protection from a P. falciparum blood-stage challenge that showed an unintendedly enhanced pathogenicity was not observed.

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