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Infect. Immun., Jan 1998, 52-58, Vol 66, No. 1
Copyright © 1998, American Society for Microbiology

Effect of prior experimental human enteropathogenic Escherichia coli infection on illness following homologous and heterologous rechallenge

MS Donnenberg, CO Tacket, G Losonsky, G Frankel, JP Nataro, G Dougan and MM Levine
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA. mdonnenb@umabnet.ab.umd.edu

Two studies of adult volunteers were performed to determine whether prior enteropathogenic Escherichia coli (EPEC) infection confers protective immunity against rechallenge. In the first study, a naive control group and volunteers who had previously ingested an O55:H6 strain were fed an O127:H6 strain. In the second study, a control group and volunteers who had previously ingested either the O127:H6 strain or an isogenic eae deletion mutant of that strain were challenged with the homologous wild-type strain. There was no significant effect of prior infection on the incidence of diarrhea in either study. However, in the homologous-rechallenge study, disease was significantly milder in the group previously challenged with the wild-type strain. Disease severity was inversely correlated with the level of prechallenge serum immunoglobulin G against the O127 lipopolysaccharide. These studies indicate that prior EPEC infection can reduce disease severity upon homologous challenge. Further studies may require the development of new model systems.


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