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Infection and Immunity, October 1998, p. 4947-4949, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Production of Interleukin-12 by Murine Macrophages in Response to Bacterial Peptidoglycan

Christine Lawrence, and Charles Nauciel*

Laboratoire de Microbiologie, Faculté de Médecine de Paris-Ouest, 92380 Garches, France

Received 19 March 1998/Returned for modification 24 April 1998/Accepted 21 July 1998

Peptidoglycan (PG), a component of the bacterial cell wall, has various immunomodulating activities, including the capacity to induce delayed-type hypersensitivity reactions to antigens administered in Freund's adjuvant. We report that PG induces interleukin-12 (IL-12) mRNA production and IL-12 secretion by mouse macrophages. The capacity of PG to induce IL-12 production, like its previously reported immunomodulating activities, was dependent on the structure of its peptide subunit. PG from Bacillus megaterium and Staphylococcus aureus induced IL-12 production, whereas PG from Micrococcus luteus and Corynebacterium poinsettiae did not. The ability of most bacterial PGs to induce IL-12 production suggests that they play an important role in triggering host defense mechanisms against bacterial infections.

* Corresponding author. Mailing address: Laboratoire de Microbiologie, Faculté de Médecine Paris-Ouest, 104 bd R. Poincaré, 92380 Garches, France. Phone: 33-1 47 10 79 50. Fax: 33-1 47 10 79 49. E-mail: charles.nauciel{at}rpc.ap-hop-paris.fr.

Infection and Immunity, October 1998, p. 4947-4949, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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