IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hu, W.-G.
Right arrow Articles by Jia, Z.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hu, W.-G.
Right arrow Articles by Jia, Z.-C.

 Previous Article  |  Next Article 

Infection and Immunity, October 1998, p. 4971-4975, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Localization of a T-Cell Epitope of Superantigen Toxic Shock Syndrome Toxin 1 to Residues 125 to 158

Wei-Gang Hu,* Xi-Hua Zhu, Yu-Zhang Wu, and Zheng-Cai Jia

Department of Immunology, The Third Military Medical University, Chongqing 400038, People's Republic of China

Received 30 April 1998/Returned for modification 27 May 1998/Accepted 8 July 1998

Toxic shock syndrome toxin 1 (TSST-1) is a member of the staphylococcal enterotoxin superantigen family. So far, little is known about T-cell epitopes on superantigens. In this study, we developed an improved method for localizing T-cell epitopes on superantigens that involved synthetic peptides plus costimulation by CD28 or phorbol myristate acetate. Using this method, we localized a T-cell epitope to a 34-residue region, TSST-1 (residues 125 to 158), which possessed only two of four TSST-1-targeted beta -chain variable element (Vbeta ) specificities of T-cell receptors in humans and mice, human Vbeta 2 and murine Vbeta 15.

* Corresponding author. Present address: Section on Experimental Immunology, Lab. of Immunology, NIDCD, 5 RC, 2A31, Rockville, MD 20850-3227. Phone: (301) 402-2581. Fax: (301) 402-4200. E-mail: wghu{at}hotmail.com.

Infection and Immunity, October 1998, p. 4971-4975, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 1998 by the American Society for Microbiology. All rights reserved.