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Infection and Immunity, October 1998, p. 4971-4975, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Localization of a T-Cell Epitope of Superantigen Toxic Shock Syndrome Toxin 1 to Residues 125 to 158

Wei-Gang Hu,* Xi-Hua Zhu, Yu-Zhang Wu, and Zheng-Cai Jia

Department of Immunology, The Third Military Medical University, Chongqing 400038, People's Republic of China

Received 30 April 1998/Returned for modification 27 May 1998/Accepted 8 July 1998

Toxic shock syndrome toxin 1 (TSST-1) is a member of the staphylococcal enterotoxin superantigen family. So far, little is known about T-cell epitopes on superantigens. In this study, we developed an improved method for localizing T-cell epitopes on superantigens that involved synthetic peptides plus costimulation by CD28 or phorbol myristate acetate. Using this method, we localized a T-cell epitope to a 34-residue region, TSST-1 (residues 125 to 158), which possessed only two of four TSST-1-targeted beta -chain variable element (Vbeta ) specificities of T-cell receptors in humans and mice, human Vbeta 2 and murine Vbeta 15.

* Corresponding author. Present address: Section on Experimental Immunology, Lab. of Immunology, NIDCD, 5 RC, 2A31, Rockville, MD 20850-3227. Phone: (301) 402-2581. Fax: (301) 402-4200. E-mail: wghu{at}hotmail.com.

Infection and Immunity, October 1998, p. 4971-4975, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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