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Infection and Immunity, October 1998, p. 5031-5035, Vol. 66, No. 10
Departments of Veterinary and Biomedical
Sciences, University of Nebraska
Received 27 March 1998/Returned for modification 18 May
1998/Accepted 16 July 1998
Pigs infected with hemolytic F4+ strains of
enterotoxigenic Escherichia coli often develop septicemia
secondary to intestinal infection. We tested the hypothesis that
inactivation of hemolysin would reduce the ability of F4+
enterotoxigenic E. coli to cause septicemia in swine
following oral inoculation. Inactivation of the hemolysin structural
gene (hlyA) did not decrease the incidence of septicemia in
the gnotobiotic piglet model.
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Pathogenicity of an Enterotoxigenic
Escherichia coli Hemolysin (hlyA) Mutant in
Gnotobiotic Piglets

Lincoln, Lincoln, Nebraska
685831;
Department of Veterinary
Science, South Dakota State University, Brookings, South Dakota
570072; and
Department of Medical
Microbiology and Immunology, University of Wisconsin, Madison,
Wisconsin 537063
*
Corresponding author. Mailing address: 111 VBS,
University of Nebraska
Lincoln, Fair St. and East Campus Loop,
Lincoln, NE 68583-0905. Phone: (402) 472-8460. Fax: (402) 472-9690. E-mail: vets044{at}unlvm.unl.edu.
Published as journal series no. 12184 of the Agricultural Research
Division, University of Nebraska.
Present address: Department of Internal Medicine, Division of
Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
48109.
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