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Infection and Immunity, October 1998, p. 5048-5051, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effective, Nonsensitizing Vaccination with Culture Filtrate Proteins against Virulent Mycobacterium bovis Infections in Mice

Catharine M. Bosio,* and Ian M. Orme

Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523

Received 14 January 1998/Returned for modification 23 March 1998/Accepted 7 July 1998

Vaccination of mice with Mycobacterium bovis culture filtrate proteins (CFP), prepared in a variety of adjuvants (aluminum hydroxide, Quil-A, and dimethyldioctyldecyl ammonium bromide [DDA]), provided significant protection against an aerosol challenge of virulent M. bovis. Additionally, vaccination with CFP in DDA or Quil-A did not sensitize mice to M. bovis purified protein derivative.

* Corresponding author. Present address: Laboratory of Mycobacteria, Division of Bacterial Products, CBER/FDA, 1401 Rockville Pike, HFM 431, Rockville, MD 20852. Phone: (301) 496-5850. Fax: (301) 402-2776. E-mail: bosio{at}cber.fda.gov.

Infection and Immunity, October 1998, p. 5048-5051, Vol. 66, No. 10
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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