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Infection and Immunity, November 1998, p. 5388-5392, Vol. 66, No. 11
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Streptococcal Adhesion System for Salivary Pellicle and Platelets

Ke Gong, T. Ouyang, and M. C. Herzberg*

Department of Preventive Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455

Received 4 May 1998/Returned for modification 19 June 1998/Accepted 10 August 1998

A Streptococcus sanguis 133-79 adhesin identified by the monoclonal antibody 1.1 (MAb 1.1) binds both saliva-coated hydroxylapatite (sHA) and platelets. The complementary binding site(s) for the adhesin was identified by the anti-idiotypical MAb 2.1. To learn if this adhesion system, marked by the antiadhesin MAb 1.1 and anti-binding site MAb 2.1, is commonly used by strains within the sanguis group and other viridans group streptococci, 42 strains from seven species were tested. Strains that bind to both sHA and platelets use the same adhesin and binding site epitopes. Strains that do not adhere to platelets rely on other adhesin specificities to bind to sHA.

* Corresponding author. Mailing address: 17-164 Moos Tower, University of Minnesota, 515 Delaware St., S.E., Minneapolis, MN 55455-0348. Phone: (612) 625-8404. Fax: (612) 626-2651. E-mail: mcherzb{at}tc.umn.edu.

Infection and Immunity, November 1998, p. 5388-5392, Vol. 66, No. 11
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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