IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Regnath, T.
Right arrow Articles by Hahn, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Regnath, T.
Right arrow Articles by Hahn, H.

 Previous Article  |  Next Article 

Infection and Immunity, November 1998, p. 5534-5536, Vol. 66, No. 11
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Murine Model of Bartonella henselae Infection in the Immunocompetent Host

T. Regnath,* M. E. A. Mielke, M. Arvand, and H. Hahn

Institute of Infectious Diseases, University Hospital Benjamin Franklin, Free University of Berlin, 12203 Berlin, Germany

Received 24 March 1998/Returned for modification 20 May 1998/Accepted 13 July 1998

Bartonella henselae is an emerging pathogen causing cat scratch disease, bacillary angiomatosis, and peliosis hepatis. Progress in understanding the pathogenesis of and the immune response to these infections has been limited by the lack of an animal model. Following intraperitoneal infection of C57BL/6 mice with B. henselae, organs were cleared of cultivatable bacteria within 6 days. In contrast, B. henselae DNA could be detected in liver tissue for at least 3 months. Liver tissue showed granulomatous inflammation reaching its highest degree of intensity during the fourth week of infection and resolving within 12 weeks postinfection. This mouse model is applicable to the study of the pathogenesis of B. henselae and the immune response to this pathogen in the immunocompetent host.

* Corresponding author. Mailing address: Institute of Infectious Diseases, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 27, D-12203 Berlin, Germany. Phone: 49 30 8445 3620. Fax: 49 30 8445 3830. E-mail: regnath{at}zedat.fu-berlin.de.

Infection and Immunity, November 1998, p. 5534-5536, Vol. 66, No. 11
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 1998 by the American Society for Microbiology. All rights reserved.