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Infection and Immunity, November 1998, p. 5543-5546, Vol. 66, No. 11
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Antrum- and Corpus Mucosa-Infiltrating CD4+ Lymphocytes in Helicobacter pylori Gastritis Display a Th1 Phenotype

Frank Sommer,1,* Gerhard Faller,2 Peter Konturek,3 Thomas Kirchner,2 Eckhart G. Hahn,3 Jürgen Zeus,4 Martin Röllinghoff,1 and Michael Lohoff1

Institut für Klinische Mikrobiologie, Immunologie und Hygiene der Universität Erlangen-Nürnberg,1 Institut für Pathologie der Universität Erlangen-Nürnberg,2 Medizinische Klinik I der Universität Erlangen-Nürnberg,3 and Praxis für Innere Medizin,4 Erlangen, Germany

Received 15 May 1998/Returned for modification 29 June 1998/Accepted 5 August 1998

In this study, cytokine patterns produced by CD4+ T cells isolated from antrum or corpus gastral biopsy specimens of 10 patients with Helicobacter pylori-positive gastritis were compared. To this end, expression of intracellular cytokines (interleukin-4 [IL-4] and gamma interferon) and of CD4 was assessed by flow cytometry. Ten to 60% of the isolated CD4+ T cells produced gamma interferon upon stimulation. With the exception of one patient, IL-4-positive CD4+ cells were not detected. Therefore, CD4+ cells infiltrating antrum and corpus stomach mucosa during H. pylori infection show a Th1 phenotype. This polarized Th1-type response may contribute to the inability of the immune system to eradicate H. pylori infection.

* Corresponding author. Mailing address: Institut für Klinische Mikrobiologie, Immunologie und Hygiene der Universität Erlangen-Nürnberg, Wasserturmstr. 3, 91054 Erlangen, Germany. Phone: 49/9131/852577. Fax: 49/9131/852573. E-mail: sommer{at}mikrobio.med.uni.erlangen.de.

Infection and Immunity, November 1998, p. 5543-5546, Vol. 66, No. 11
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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