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Infection and Immunity, November 1998, p. 5576-5579, Vol. 66, No. 11
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Characterization of a 34-Kilodalton Protein of Mycobacterium leprae That Is Isologous to the Immunodominant 34-Kilodalton Antigen of Mycobacterium paratuberculosis

Fauzi S. Silbaq,1 Sang-Nae Cho,1,dagger Stewart T. Cole,2 and Patrick J. Brennan1,*

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523,1 and Institut Pasteur, Paris, France2

Received 19 December 1997/Returned for modification 29 January 1998/Accepted 26 June 1998

During DNA sequence analysis of cosmid L373 from the Mycobacterium leprae genome, an open reading frame of 1.4 kb encoding a protein with some homology to the immunodominant 34-kDa protein of Mycobacterium paratuberculosis, but lacking significant serological activity, was detected. The DNA sequence predicted a signal peptide with a modified lipoprotein consensus sequence, but the protein proved to be devoid of lipid attachment.

* Corresponding author. Mailing address: Department of Microbiology, Colorado State University, Fort Collins, CO 80523. Phone: (970) 491-6700. Fax: (970) 491-1815. E-mail: pbrennan{at}cvmbs.colostate.edu.

dagger Permanent address: Department of Microbiology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Infection and Immunity, November 1998, p. 5576-5579, Vol. 66, No. 11
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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