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Infection and Immunity, December 1998, p. 6004-6009, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Hemagglutination-Positive Phenotype of Mycoplasma synoviae Induces Experimental Infectious Synovitis in Chickens More Frequently than Does the Hemagglutination-Negative Phenotype

M. Narat,1 D. Bencina,1,* S. H. Kleven,2 and F. Habe1

Department of Animal Science, Biotechnical Faculty, University of Ljubljana, 1230 Domzale, Slovenia,1 and Department of Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602-48752

Received 21 May 1998/Returned for modification 22 July 1998/Accepted 24 September 1998

Inoculation with hemagglutination-positive (HA+) cultures of Mycoplasma synoviae AAY-4 induced acute synovitis significantly more frequently (P = 0.001) in chicken tibiotarsal-tarsometatarsal joints than did inoculation with HA-negative (HA-) cultures derived from the same clone of AAY-4. Immunoblotting analyses showed that HA+ cultures abundantly expressed two phase-variable hemadherence-associated surface membrane proteins of 53 kDa and 48 to 50 kDa defined by monoclonal antibodies. HA- cultures lacked the 53-kDa proteins and synthesized truncated 27- to 30-kDa forms of the 48- to 50-kDa proteins. Inoculation of cyclosporin A (CsA) into infected joints significantly decreased the frequency of acute synovitis (P = 0.001). Moreover, repeated intra-articular inoculation of CsA (three doses of 1 mg at 2-day intervals) significantly reduced the local antibody response to M. synoviae in the joints treated with CsA.

* Corresponding author. Mailing address: Department of Animal Science, Biotechnical Faculty, University of Ljubljana, 1230 Domzale, Slovenia. Phone: (386 61) 717 809. Fax: (386 61) 721 005. E-mail: dusan.bencina{at}bfro.uni-lj.si.

Infection and Immunity, December 1998, p. 6004-6009, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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