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Infection and Immunity, December 1998, p. 6017-6021, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Chlamydia trachomatis IncA Is Localized to the Inclusion Membrane and Is Recognized by Antisera from Infected Humans and Primatesdagger

John P. Bannantine,1 Walter E. Stamm,2 Robert J. Suchland,2 and Daniel D. Rockey1,*

Department of Microbiology, Oregon State University, Corvallis, Oregon 97331-3804,1 and Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, Washington 98195-65232

Received 22 June 1998/Returned for modification 29 July 1998/Accepted 11 September 1998

Chlamydia psittaci produces a collection of proteins, termed IncA, IncB, and IncC, that are localized to the chlamydial inclusion membrane. In this report we demonstrate that IncA is also produced by Chlamydia trachomatis. C. trachomatis IncA is structurally similar to C. psittaci IncA and is also localized to the inclusion membrane. Immunoblot analysis demonstrated that sera from C. trachomatis-infected patients and from experimentally infected monkeys both recognized C. trachomatis IncA.

* Corresponding author. Mailing address: Oregon State University, Department of Microbiology, 220 Nash Hall, Corvallis, OR 97331-3804. Phone: (541) 737-1848. Fax: (541) 737-0496. E-mail: rockeyd{at}ucs.orst.edu.

dagger Technical paper 11411 of the Oregon State University Extension and Experiment Station.

Infection and Immunity, December 1998, p. 6017-6021, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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