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Infection and Immunity, December 1998, p. 6022-6023, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Correlation of Cecal Microflora of HLA-B27 Transgenic Rats with Inflammatory Bowel Disease

Andrew B. Onderdonk,1,* James A. Richardson,2 Robert E. Hammer,3 and Joel D. Taurog4

Channing Laboratory, Departments of Medicine and Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,1 and Department of Pathology, Howard Hughes Medical Institute2 and Department of Biochemistry,3 and Harold C. Simmons Arthritis Research Center and Department of Internal Medicine,4 University of Texas Southwestern Medical Center, Dallas, Texas 75235

Received 1 June 1998/Returned for modification 13 July 1998/Accepted 23 September 1998

Transgenic rats with a high level of expression of the human major histocompatibility complex class I molecule HLA-B27 develop chronic inflammatory bowel disease (IBD) and arthritis. Assessment of the cecal microflora showed a rise in numbers of Escherichia coli and Enterococcus spp., corresponding to the presence and severity of IBD in these rats.

* Corresponding author. Mailing address: Channing Laboratory, 181 Longwood Ave., Boston, MA 02115. Phone: (617) 732-7372. Fax: (617) 731-1541. E-mail: ABONDERDON{at}BICS.BWH.HARVARD.EDU.

Infection and Immunity, December 1998, p. 6022-6023, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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