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Infection and Immunity, December 1998, p. 6027-6029, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Contrasting Roles of Mannan-Specific Monoclonal Immunoglobulin M Antibodies in the Activation of Classical and Alternative Pathways by Candida albicans

Mason X. Zhang,1,* Jim E. Cutler,2 Yongmoon Han,2 and Thomas R. Kozel1

Department of Microbiology and the Cell and Molecular Biology Program, School of Medicine, University of Nevada, Reno, Nevada 89557,1 and Department of Microbiology, Montana State University, Bozeman, Montana 597172

Received 29 June 1998/Returned for modification 12 August 1998/Accepted 17 September 1998

Polyclonal antimannan immunoglobulin G (IgG) activates the classical complement pathway and accelerates initiation of the alternative pathway by Canidida albicans. This dual role was assessed for two antimannan IgM monoclonal antibodies (MAbs). MAb B6.1 is specific for an epitope on the acid-labile portion of C. albicans phosphomannan; MAb B6 is specific for an epitope on the acid-stable region. Both MAbs were potent activators of the classical pathway but poor facilitators of alternative pathway initiation.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, University of Nevada, Reno, NV 89557. Phone: (702) 784-6161. Fax: (702) 784-1620. E-mail: mzhang{at}med.unr.edu.

Infection and Immunity, December 1998, p. 6027-6029, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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