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Infection and Immunity, December 1998, p. 6030-6034, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Phagocytic and Tumor Necrosis Factor Alpha Response of Human Mast Cells following Exposure to Gram-Negative and Gram-Positive Bacteria

Michel Arock,1 Elaine Ross,2 René Lai-Kuen,1 Geneviève Averlant,1 Zhimin Gao,2 and Soman N. Abraham2,*

Departments of Cellular and Molecular Hematology and Electron Microscopy, Faculty of Pharmacy, 75270 Paris Cedex 06, France,1 and Departments of Pathology and Microbiology, Duke University Medical Center, Durham, North Carolina 277102

Received 22 May 1998/Returned for modification 12 July 1998/Accepted 19 August 1998

Recent studies have implicated rodent mast cells in the innate immune response to infectious bacteria. We report that cord blood-derived human mast cells (CBHMC) obtained from culture of cord blood progenitors phagocytozed and killed various gram-negative and gram-positive bacteria and simultaneously released considerable amounts of tumor necrosis factor alpha. Overall, the extent of the endocytic and exocytic response of CBHMC correlated with the number of adherent bacteria. Thus, human mast cells are intrinsically capable of mediating microbial recognition and of actively contributing to the host defense against bacteria.

* Corresponding author. Mailing address: Department of Pathology, Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-3630. Fax: (919) 684-2021. E-mail: abrah006{at}mc.duke.edu.

Infection and Immunity, December 1998, p. 6030-6034, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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