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Infection and Immunity, December 1998, p. 6040-6044, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Reciprocal Regulation of Th1- and Th2-Cytokine-Producing T Cells during Clearance of Parasitemia in Plasmodium falciparum Malaria

Stefan Winkler,1,2,* Martin Willheim,3 Karin Baier,3 Daniela Schmid,1,2 Alexander Aichelburg,1,2 Wolfgang Graninger,1 and Peter G. Kremsner2,4

Department of Internal Medicine, Division of Infectious Diseases,1 and Institute of General and Experimental Pathology,3 University of Vienna, Vienna, Austria; Research Unit of the Albert Schweitzer Hospital, Lambaréné, Gabon2; and Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany4

Received 7 July 1998/Returned for modification 11 August 1998/Accepted 4 September 1998

Flow cytometry for the intracellular detection of T-cell cytokines was performed for 15 Gabonese patients during acute uncomplicated Plasmodium falciparum malaria. A striking expansion of CD4+ and CD8+ T cells producing gamma interferon (IFN-gamma ) was found during drug-induced clearance of parasitemia, paralleled by a decrease of interleukin-2 (IL-2) production. The frequency of IL-4- and IL-13-producing CD4+ cells gradually decreased, whereas the frequency of T cells producing IL-2+-IFN-gamma +, IL-4--IL-5+, and IL-4+-IL-5+ cytokines as well as IL-4+-IFN-gamma + and IL-13+-IFN-gamma + cytokines was not significantly altered. The capacity for IL-10 production within the CD4+ subset increased due to an expansion of both IL-10+-IFN-gamma - and IL-10+-IFN-gamma + cytokine-expressing cells. Thus, a more pronounced Th2-driven immune response during acute untreated P. falciparum infection with a shift towards Th1 responsiveness induced by parasite clearance is suggested.

* Corresponding author. Mailing address: Department of Internal Medicine, Division of Infectious Diseases, University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria. Phone: 43 1 40400 4440. Fax: 43 1 40400 4418. E-mail: stefan.winkler{at}akh-wien.ac.at.

Infection and Immunity, December 1998, p. 6040-6044, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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