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Infection and Immunity, December 1998, p. 6058-6062, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Lactobacilli and Streptococci Induce Interleukin-12 (IL-12),
IL-18, and Gamma Interferon Production in Human Peripheral Blood
Mononuclear Cells
Minja
Miettinen,1,2,*
Sampsa
Matikainen,1
Jaana
Vuopio-Varkila,2
Jaana
Pirhonen,1
Kari
Varkila,3
Masashi
Kurimoto,4 and
Ilkka
Julkunen1
Department of
Virology1 and
Department of
Bacteriology,2 National Public Health Institute,
00300 Helsinki, and
Orion Pharma, 02101 Espoo,3 Finland, and
Fujisaki Institute,
Hayashibara Biochemical Laboratories Inc., 675-1 Fujisaki, Okayama
702-8006, Japan4
Received 8 April 1998/Returned for modification 10 August
1998/Accepted 4 September 1998
Human peripheral blood mononuclear cells (PBMC) were stimulated
with three nonpathogenic Lactobacillus strains and with one pathogenic Streptococcus pyogenes strain, and cytokine gene
expression and protein production were analyzed. All bacteria
strongly induced interleukin-1
(IL-1
), IL-6, and tumor necrosis
factor alpha mRNA expression and protein production. S. pyogenes was the most potent inducer of secretion of IL-12 and
gamma interferon (IFN-
), and two of three Lactobacillus
strains induced IL-12 and IFN-
production. All strains induced IL-18
protein production. IL-10 and IL-4 production was induced weakly and
not at all, respectively. Our data show that nonpathogenic
lactobacilli and pathogenic streptococci can induce Th1 type cytokines
IL-12, IL-18, and IFN-
in human PBMC.
*
Corresponding author. Mailing address: Department of
Virology, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland. Phone: 358-9-47448303. Fax: 358-9-47448355. E-mail:
minja.miettinen{at}ktl.fi.
Infection and Immunity, December 1998, p. 6058-6062, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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