Lactobacilli and Streptococci Induce Interleukin-12 (IL-12), IL-18, and Gamma Interferon Production in Human Peripheral Blood Mononuclear Cells

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Infection and Immunity, December 1998, p. 6058-6062, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Lactobacilli and Streptococci Induce Interleukin-12 (IL-12), IL-18, and Gamma Interferon Production in Human Peripheral Blood Mononuclear Cells

Minja Miettinen,¹^,²^,^* Sampsa Matikainen,¹ Jaana Vuopio-Varkila,² Jaana Pirhonen,¹ Kari Varkila,³ Masashi Kurimoto,⁴ and Ilkka Julkunen¹

Department of Virology¹ and Department of Bacteriology,² National Public Health Institute, 00300 Helsinki, and Orion Pharma, 02101 Espoo,³ Finland, and Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., 675-1 Fujisaki, Okayama 702-8006, Japan⁴

Received 8 April 1998/Returned for modification 10 August 1998/Accepted 4 September 1998

Human peripheral blood mononuclear cells (PBMC) were stimulated with three nonpathogenic Lactobacillus strains and with onepathogenic Streptococcus pyogenes strain, and cytokine gene expressionand protein production were analyzed. All bacteria strongly inducedinterleukin-1 $beta$ (IL-1 $beta$ ), IL-6, and tumor necrosis factor alphamRNA expression and protein production. S. pyogenes was the mostpotent inducer of secretion of IL-12 and gamma interferon (IFN- $gamma$ ),and two of three Lactobacillus strains induced IL-12 and IFN- $gamma$ production. All strains induced IL-18 protein production. IL-10and IL-4 production was induced weakly and not at all, respectively.Our data show that nonpathogenic lactobacilli and pathogenic streptococcican induce Th1 type cytokines IL-12, IL-18, and IFN- $gamma$ in humanPBMC.

^* Corresponding author. Mailing address: Department of Virology, National Public Health Institute, Mannerheimintie 166, 00300Helsinki, Finland. Phone: 358-9-47448303. Fax: 358-9-47448355.E-mail: minja.miettinen{at}ktl.fi.

Infection and Immunity, December 1998, p. 6058-6062, Vol. 66, No. 12
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

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