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Infect Immun, February 1998, p. 760-764, Vol. 66, No. 2
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Increased Resistance to Taenia crassiceps Murine Cysticercosis in Qa-2 Transgenic Mice

Gladis Fragoso,1 Edmundo Lamoyi,1 Andrew Mellor,2 Ciro Lomelí,1 Marisela Hernández,1 and Edda Sciutto1,*

Department of Immunology, Instituto de Investigaciones Biomédicas, UNAM, México D.F. 04510, México,1 and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 309122

Received 21 April 1997/Returned for modification 23 July 1997/Accepted 4 November 1997

We previously reported important differences in resistance to Taenia crassiceps murine cysticercosis between BALB/c substrains. It was suggested that resistance might correlate with expression of the nonclassic class I major histocompatibility complex (MHC) Qa-2 antigen; BALB/cAnN is Qa-2 negative and highly susceptible to T. crassiceps, whereas BALB/cJ expresses Qa-2 and is highly resistant. In this study, we investigated the role of Qa-2 in mediating resistance to cysticercosis by linkage analysis and infection of Qa-2 transgenic mice. In BALB/cAnN × (C57BL/6J × BALB/cAnN)F1 and BALB/cAnN × (BALB/cJ × BALB/cAnN)F1 backcrosses, the expression of Qa-2 antigen correlated with resistance to cysticercosis. Significantly fewer parasites were recovered from infected Qa-2 transgenic male and female mice than from nontransgenic mice of similar genetic background. These results clearly demonstrate that the Qa-2 MHC antigen is involved in resistance to T. crassiceps cysticercosis.

* Corresponding author. Mailing address: Departamento de Inmunología, Instituto de Investigaciones Biomédicas, UNAM, Apartado Postal 70-228, México D.F. 04510, México. Phone: (525) 622-38-18. Fax: (525) 550-00-48. E-mail: edda{at}servidor.unam.mx.




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