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Infect Immun, February 1998, p. 820-822, Vol. 66, No. 2
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Adherence of Streptococcus pneumoniae to Human Bronchial Epithelial Cells (BEAS-2B)

John E. Adamou, Theresa M. Wizemann, Philip Barren, and Solomon Langermann*

Department of Immunology and Molecular Genetics, MedImmune, Inc., Gaithersburg, Maryland 20878

Received 1 August 1997/Returned for modification 16 October 1997/Accepted 18 November 1997

Pneumococcal adherence to alveolar epithelial cells and nasopharyngeal epithelial cells has been well characterized. However, the interaction of Streptococcus pneumoniae with bronchial epithelial cells has not been studied. We have now shown that pneumococci bind specifically to a human bronchial epithelial cell line (BEAS-2B cells). Pneumococci adhered to BEAS-2B cells in a time- and dose-dependent manner. These results suggest that the bronchial epithelium may serve as an additional site of attachment for pneumococci and demonstrate the utility of the BEAS-2B cell line for studying mechanisms of pneumococcal infection.

* Corresponding author. Mailing address: MedImmune, Incorporated, 35 W. Watkins Mill Rd., Gaithersburg, MD 20878. Phone: (301) 527-4320. Fax: (301) 527-4200. E-mail: langermanns{at}medimmune.com.




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