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Infect Immun, February 1998, p. 827-829, Vol. 66, No. 2
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Analysis of the Immune Responses of Mice to Infection with Leishmania braziliensis

Gregory K. DeKrey, Hermenio C. Lima,dagger and Richard G. Titus*

Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523-1671

Received 5 June 1997/Returned for modification 18 July 1997/Accepted 21 November 1997

Leishmania major and Leishmania braziliensis both cause cutaneous leishmaniasis, but the former kills BALB/c mice while the latter is killed by the mice. This killing of L. braziliensis occurred by a gamma interferon-dependent mechanism, potentially made possible by the observed lack of high interleukin-4 production.

* Corresponding author. Mailing address: Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1671. Phone: (970) 491-4964. Fax: (970) 491-0603. E-mail: rtitus{at}vines.colostate.edu.

dagger Present address: Departamento de Parasitologia, Microbiologia e Imunologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo---Campus de Ribeirao Preto, Ribeirao Preto SP 14.049- 900, Brazil.




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