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Infect Immun, February 1998, p. 835-838, Vol. 66, No. 2
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Inducible Nitric Oxide Synthase Does Not Affect Resolution of Murine Chlamydial Genital Tract Infections or Eradication of Chlamydiae in Primary Murine Cell Culture

Kyle H. Ramsey,1,* Gurwattan S. Miranpuri,2 Christoffer E. Poulsen,1 Nancy B. Marthakis,1 Laima M. Braune,1 and Gerald I. Byrne2

Microbiology Department, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515,1 and Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 537062

Received 10 September 1997/Returned for modification 22 October 1997/Accepted 11 November 1997

Mice lacking inducible nitric oxide synthase (iNOS) or treated with iNOS inhibitors resolved chlamydial genital tract infections. Additionally, treatment of primary murine cell cultures with gamma interferon restricted chlamydial growth in the absence of nitric oxide. From these results, iNOS activity is unnecessary for the resolution of chlamydial genital tract infections in mice and inhibition of chlamydial growth in culture.

* Corresponding author. Mailing address: Microbiology Department, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st St., Downers Grove, IL 60515. Phone: (630) 515-6165. Fax: (630) 515-7245. E-mail: kramse{at}midwestern.edu.




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