This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ramsey, K. H.
Right arrow Articles by Byrne, G. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ramsey, K. H.
Right arrow Articles by Byrne, G. I.

 Previous Article  |  Next Article 

Infect Immun, February 1998, p. 835-838, Vol. 66, No. 2
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Inducible Nitric Oxide Synthase Does Not Affect Resolution of Murine Chlamydial Genital Tract Infections or Eradication of Chlamydiae in Primary Murine Cell Culture

Kyle H. Ramsey,1,* Gurwattan S. Miranpuri,2 Christoffer E. Poulsen,1 Nancy B. Marthakis,1 Laima M. Braune,1 and Gerald I. Byrne2

Microbiology Department, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515,1 and Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 537062

Received 10 September 1997/Returned for modification 22 October 1997/Accepted 11 November 1997

Mice lacking inducible nitric oxide synthase (iNOS) or treated with iNOS inhibitors resolved chlamydial genital tract infections. Additionally, treatment of primary murine cell cultures with gamma interferon restricted chlamydial growth in the absence of nitric oxide. From these results, iNOS activity is unnecessary for the resolution of chlamydial genital tract infections in mice and inhibition of chlamydial growth in culture.

* Corresponding author. Mailing address: Microbiology Department, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st St., Downers Grove, IL 60515. Phone: (630) 515-6165. Fax: (630) 515-7245. E-mail: kramse{at}midwestern.edu.




This article has been cited by other articles:

  • Cheng, W., Shivshankar, P., Li, Z., Chen, L., Yeh, I-T., Zhong, G. (2008). Caspase-1 Contributes to Chlamydia trachomatis-Induced Upper Urogenital Tract Inflammatory Pathologies without Affecting the Course of Infection. Infect. Immun. 76: 515-522 [Abstract] [Full Text]  
  • Giles, T. N., Graham, D. E. (2007). Characterization of an Acid-Dependent Arginine Decarboxylase Enzyme from Chlamydophila pneumoniae. J. Bacteriol. 189: 7376-7383 [Abstract] [Full Text]  
  • Sakai, K., Suzuki, H., Oda, H., Akaike, T., Azuma, Y., Murakami, T., Sugi, K., Ito, T., Ichinose, H., Koyasu, S., Shirai, M. (2006). Phosphoinositide 3-Kinase in Nitric Oxide Synthesis in Macrophage: CRITICAL DIMERIZATION OF INDUCIBLE NITRIC-OXIDE SYNTHASE. J. Biol. Chem. 281: 17736-17742 [Abstract] [Full Text]  
  • Roshick, C., Wood, H., Caldwell, H. D., McClarty, G. (2006). Comparison of Gamma Interferon-Mediated Antichlamydial Defense Mechanisms in Human and Mouse Cells. Infect. Immun. 74: 225-238 [Abstract] [Full Text]  
  • Nagarajan, U. M., Ojcius, D. M., Stahl, L., Rank, R. G., Darville, T. (2005). Chlamydia trachomatis Induces Expression of IFN-{gamma}-Inducible Protein 10 and IFN-{beta} Independent of TLR2 and TLR4, but Largely Dependent on MyD88. J. Immunol. 175: 450-460 [Abstract] [Full Text]  
  • Hogbom, M., Stenmark, P., Voevodskaya, N., McClarty, G., Graslund, A., Nordlund, P. (2004). The Radical Site in Chlamydial Ribonucleotide Reductase Defines a New R2 Subclass. Science 305: 245-248 [Abstract] [Full Text]  
  • Ramsey, K. H., Sigar, I. M., Rana, S. V., Gupta, J., Holland, S. M., Byrne, G. I., Morrow, J. D. (2003). Inducible Nitric Oxide Synthase Regulates Production of Isoprostanes In Vivo during Chlamydial Genital Infection in Mice. Infect. Immun. 71: 7183-7187 [Abstract] [Full Text]  
  • Darville, T., O'Neill, J. M., Andrews, C. W. Jr., Nagarajan, U. M., Stahl, L., Ojcius, D. M. (2003). Toll-Like Receptor-2, but Not Toll-Like Receptor-4, Is Essential for Development of Oviduct Pathology in Chlamydial Genital Tract Infection. J. Immunol. 171: 6187-6197 [Abstract] [Full Text]  
  • Hawkins, R. A., Rank, R. G., Kelly, K. A. (2002). A Chlamydia trachomatis-Specific Th2 Clone Does Not Provide Protection against a Genital Infection and Displays Reduced Trafficking to the Infected Genital Mucosa. Infect. Immun. 70: 5132-5139 [Abstract] [Full Text]  
  • Morrison, R. P., Caldwell, H. D. (2002). Immunity to Murine Chlamydial Genital Infection. Infect. Immun. 70: 2741-2751 [Full Text]  
  • Ramsey, K. H., Sigar, I. M., Rana, S. V., Gupta, J., Holland, S. M., Byrne, G. I. (2001). Role for Inducible Nitric Oxide Synthase in Protection from Chronic Chlamydia trachomatis Urogenital Disease in Mice and Its Regulation by Oxygen Free Radicals. Infect. Immun. 69: 7374-7379 [Abstract] [Full Text]  
  • Ramsey, K. H., Miranpuri, G. S., Sigar, I. M., Ouellette, S., Byrne, G. I. (2001). Chlamydia trachomatis Persistence in the Female Mouse Genital Tract: Inducible Nitric Oxide Synthase and Infection Outcome. Infect. Immun. 69: 5131-5137 [Abstract] [Full Text]  
  • Morrison, S. G., Su, H., Caldwell, H. D., Morrison, R. P. (2000). Immunity to Murine Chlamydia trachomatis Genital Tract Reinfection Involves B Cells and CD4+ T Cells but Not CD8+ T Cells. Infect. Immun. 68: 6979-6987 [Abstract] [Full Text]  
  • Rottenberg, M. E., Gigliotti Rothfuchs, A. C., Gigliotti, D., Svanholm, C., Bandholtz, L., Wigzell, H. (1999). Role of Innate and Adaptive Immunity in the Outcome of Primary Infection with Chlamydia pneumoniae, as Analyzed in Genetically Modified Mice. J. Immunol. 162: 2829-2836 [Abstract] [Full Text]  
  • Way, S. S., Goldberg, M. B. (1998). Clearance of Shigella flexneri Infection Occurs through a Nitric Oxide-Independent Mechanism. Infect. Immun. 66: 3012-3016 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»