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Infect Immun, February 1998, p. 835-838, Vol. 66, No. 2
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Inducible Nitric Oxide Synthase Does Not Affect Resolution of
Murine Chlamydial Genital Tract Infections or Eradication of
Chlamydiae in Primary Murine Cell Culture
Kyle H.
Ramsey,1,*
Gurwattan S.
Miranpuri,2
Christoffer E.
Poulsen,1
Nancy B.
Marthakis,1
Laima M.
Braune,1 and
Gerald I.
Byrne2
Microbiology Department, Chicago College of
Osteopathic Medicine, Midwestern University, Downers Grove,
Illinois 60515,1 and
Department of
Medical Microbiology and Immunology, University of Wisconsin
Medical School, Madison, Wisconsin 537062
Received 10 September 1997/Returned for modification 22 October
1997/Accepted 11 November 1997
Mice lacking inducible nitric oxide synthase (iNOS) or treated with
iNOS inhibitors resolved chlamydial genital tract infections. Additionally, treatment of primary murine cell cultures with gamma interferon restricted chlamydial growth in the absence of nitric oxide. From these results, iNOS activity is unnecessary for the resolution of chlamydial genital tract infections in mice and inhibition of chlamydial growth in culture.
*
Corresponding author. Mailing address: Microbiology
Department, Chicago College of Osteopathic Medicine, Midwestern
University, 555 31st St., Downers Grove, IL 60515. Phone: (630)
515-6165. Fax: (630) 515-7245. E-mail:
kramse{at}midwestern.edu.
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