This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jett, B. D.
Right arrow Articles by Gilmore, M. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jett, B. D.
Right arrow Articles by Gilmore, M. S.

 Previous Article  |  Next Article 

Infect Immun, February 1998, p. 843-848, Vol. 66, No. 2
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Enterococcus faecalis Localization in Experimental Endophthalmitis: Role of Plasmid-Encoded Aggregation Substance

Bradley D. Jett,1,* Rajeshwari V. Atkuri,1 and Michael S. Gilmore1,2

Department of Ophthalmology, Molecular Pathogenesis of Eye Infection Research Center, Dean A. McGee Eye Institute,1 and Department of Microbiology and Immunology,2 University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Received 29 August 1997/Returned for modification 10 October 1997/Accepted 17 November 1997

Enterococci have emerged as leading agents of nosocomial infection, yet relatively little is known about the pathogenesis of enterococcal disease. In previous studies, we developed an Enterococcus faecalis endophthalmitis infection model which provides unique opportunities to study the evolution of enterococcal disease by direct observation, as well as through sensitive electrophysiologic measures of organ function. The present study was designed to determine whether E. faecalis possesses traits that permit its attachment to mammalian tissues during infection. It was also of interest to determine whether a plasmid-encoded adhesin, aggregation substance, contributes to enterococcal localization or otherwise mediates adherence to alternate sites. These studies found that, in this model, enterococci attach to membranous structures occurring within the vitreous but that this attachment or the course or severity of disease is unaffected by the aggregation substance phenotype.

* Corresponding author. Mailing address: Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L. Young Blvd., Oklahoma City, OK 73104. Phone: (405) 271-1084. Fax: (405) 271-3013. E-mail: brad-jett{at}ouhsc.edu.




This article has been cited by other articles:

  • Kayaoglu, G., Orstavik, D. (2004). VIRULENCE FACTORS OF ENTEROCOCCUS FAECALIS: RELATIONSHIP TO ENDODONTIC DISEASE. CROBM 15: 308-320 [Abstract] [Full Text]  
  • Stentz, R., Jury, K., Eaton, T., Parker, M., Narbad, A., Gasson, M., Shearman, C. (2004). Controlled expression of CluA in Lactococcus lactis and its role in conjugation. Microbiology 150: 2503-2512 [Abstract] [Full Text]  
  • Mylonakis, E., Engelbert, M., Qin, X., Sifri, C. D., Murray, B. E., Ausubel, F. M., Gilmore, M. S., Calderwood, S. B. (2002). The Enterococcus faecalis fsrB Gene, a Key Component of the fsr Quorum-Sensing System, Is Associated with Virulence in the Rabbit Endophthalmitis Model. Infect. Immun. 70: 4678-4681 [Abstract] [Full Text]  
  • Callegan, M. C., Engelbert, M., Parke, D. W. II, Jett, B. D., Gilmore, M. S. (2002). Bacterial Endophthalmitis: Epidemiology, Therapeutics, and Bacterium-Host Interactions. Clin. Microbiol. Rev. 15: 111-124 [Abstract] [Full Text]  
  • Wells, C. L., Moore, E. A., Hoag, J. A., Hirt, H., Dunny, G. M., Erlandsen, S. L. (2000). Inducible Expression of Enterococcus faecalis Aggregation Substance Surface Protein Facilitates Bacterial Internalization by Cultured Enterocytes. Infect. Immun. 68: 7190-7194 [Abstract] [Full Text]  
  • Sartingen, S., Rozdzinski, E., Muscholl-Silberhorn, A., Marre, R. (2000). Aggregation Substance Increases Adherence and Internalization, but Not Translocation, of Enterococcus faecalis through Different Intestinal Epithelial Cells In Vitro. Infect. Immun. 68: 6044-6047 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»