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Infect Immun, March 1998, p. 1244-1247, Vol. 66, No. 3
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Specific Antibody to Cryptococcus neoformans Alters Human Leukocyte Cytokine Synthesis and Promotes T-Cell Proliferation

Anna Vecchiarelli,1,* Cinzia Retini,1 Claudia Monari,1 and Arturo Casadevall2

Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy,1 and Department of Medicine and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 104612

Received 11 September 1997/Returned for modification 25 October 1997/Accepted 4 December 1997

Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1beta (IL-1beta ), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. The ability of specific antibody to influence cytokine production and lymphoproliferation suggests a mechanism by which humoral immunity can influence cell-mediated immunity.

* Corresponding author. Mailing address: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy. Phone: 39-75-585-3407. Fax: 39-75-585-3400. E-mail: vecchiar{at}unipg.it.




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