Serum Complement Sensitivity as a Key Factor in Lyme Disease Ecology

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Infect Immun, March 1998, p. 1248-1251, Vol. 66, No. 3
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Serum Complement Sensitivity as a Key Factor in Lyme Disease Ecology

Klaus Kurtenbach,¹^,²^,^* Henna-Sisko Sewell,¹^,² Nick H. Ogden,³ Sarah E. Randolph,¹ and Patricia A. Nuttall²

Department of Zoology, University of Oxford, Oxford OX1 3PS,¹ NERC Institute of Virology and Environmental Microbiology, Oxford OX1 3SR,² and Department of Veterinary Clinical Medicine, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX,³ United Kingdom

Received 15 October 1997/Returned for modification 17 November 1997/Accepted 10 December 1997

The sensitivity of Borrelia burgdorferi sensu lato to animal sera was analyzed. Complement-mediated borreliacidal effectswere observed with particular combinations of host serum and Borreliagenospecies. The species-specific pattern of viability and/orlysis is highly consistent with the pattern of reservoir competenceof hosts for B. burgdorferi sensu lato, suggesting a key roleof complement in the global ecology of Lyme borreliosis.

^* Corresponding author. Mailing address: The Wellcome Trust Centre for the Epidemiology of Infectious Diseases, Department ofZoology, University of Oxford, South Parks Rd., Oxford OX1 3PS,United Kingdom. Phone: 44-1865-281630. Fax: 44-1865-281696. E-mail:kku{at}mail.nerc-oxford.ac.uk.

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