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Infect Immun, March 1998, p. 1265-1269, Vol. 66, No. 3
0019-9567/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Neither Interleukin-6 nor Inducible Nitric Oxide Synthase Is Required for Clearance of Chlamydia trachomatis from the Murine Genital Tract Epithelium

Linda L. Perry,* Karen Feilzer, and Harlan D. Caldwell

Laboratory of Intracellular Parasites, Immunology Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratory, Hamilton, Montana 59840

Received 9 October 1997/Returned for modification 20 November 1997/Accepted 10 December 1997

Female mice bearing targeted mutations in the interleukin-6 or inducible nitric oxide synthase locus mounted effective immune responses following vaginal infection with Chlamydia trachomatis. Chlamydial clearance rates, local Th1 cytokine production, and host antibody responses were similar to those of immunocompetent control mice. Therefore, neither gene product appears to be critical for the resolution of chlamydial infections of the urogenital epithelium.

* Corresponding author. Mailing address: Laboratory of Intracellular Parasites, Rocky Mountain Laboratory, 903 South 4th St., Hamilton, MT 59840. Phone: (406) 363-9328. Fax: (406) 363-9391. E-mail: Linda_Perry{at}nih.gov.




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